间充质干细胞衍生的细胞外囊泡在小鼠疾病模型中缓解咪喹莫特诱发的牛皮癣症状

bioRxiv - Physiology Pub Date : 2024-09-16 DOI:10.1101/2024.09.10.612372

Yuan Yi, Yu Yan, Guowu Liu, Chuang Cui, Yanhua Zhai, Ke Xu, Xinjun He

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引用次数: 0

摘要

牛皮癣是一种免疫介导的慢性炎症性皮肤病。间充质干细胞衍生的细胞外囊泡（MSC-EVs）与其亲代细胞间充质干细胞（MSCs）具有内在的免疫调节效力。本研究揭示了间充质干细胞-细胞外小泡在咪喹莫特诱导的银屑病小鼠模型中缓解银屑病症状的应用潜力。

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Mesenchymal stem cell-derived extracellular vesicles alleviate imiquimod-induced psoriasis symptoms in a mouse disease model

Psoriasis is an immune mediated, chronic inflammatory skin disease. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have inherent immunomodulatory potency from their parental cells, the mesenchymal stem cells (MSCs). In this study, we revealed the application potential of MSC-EVs to alleviate psoriatic symptoms in imiquimod-induced psoriasis mouse model.

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bioRxiv - Physiology

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