{"title":"铁催化的结构不同的 Si- 卤代二烯烃的 γ-多卤烷基化反应","authors":"Justin, Mohr, Douglas, Yarbrough, Brian, Osei-Badu, Cole, Wagner, Kayla, Storme, Sebastian, Marquez R.","doi":"10.26434/chemrxiv-2024-78vqn","DOIUrl":null,"url":null,"abstract":"Regioselective γ-polyhaloalkylation is achieved using tetrahalomethanes or α,α,α-trihaloalkyl compounds and siloxydienes via Fe(II) catalysis. A range of siloxydienes are functionalized in good yield and high stereoselectivity under mild reaction conditions. Structural divergence is observed as either haloalkylated or haloalkenylated products are formed based on substitution pattern of the siloxydiene. The halogenated products show utility in further synthetic transformations selec- tive reduction and cross coupling reactions.","PeriodicalId":9813,"journal":{"name":"ChemRxiv","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Fe-Catalyzed Structurally Divergent γ-Polyhaloalkylation of Si- loxydienes\",\"authors\":\"Justin, Mohr, Douglas, Yarbrough, Brian, Osei-Badu, Cole, Wagner, Kayla, Storme, Sebastian, Marquez R.\",\"doi\":\"10.26434/chemrxiv-2024-78vqn\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Regioselective γ-polyhaloalkylation is achieved using tetrahalomethanes or α,α,α-trihaloalkyl compounds and siloxydienes via Fe(II) catalysis. A range of siloxydienes are functionalized in good yield and high stereoselectivity under mild reaction conditions. Structural divergence is observed as either haloalkylated or haloalkenylated products are formed based on substitution pattern of the siloxydiene. The halogenated products show utility in further synthetic transformations selec- tive reduction and cross coupling reactions.\",\"PeriodicalId\":9813,\"journal\":{\"name\":\"ChemRxiv\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ChemRxiv\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26434/chemrxiv-2024-78vqn\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemRxiv","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26434/chemrxiv-2024-78vqn","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Fe-Catalyzed Structurally Divergent γ-Polyhaloalkylation of Si- loxydienes
Regioselective γ-polyhaloalkylation is achieved using tetrahalomethanes or α,α,α-trihaloalkyl compounds and siloxydienes via Fe(II) catalysis. A range of siloxydienes are functionalized in good yield and high stereoselectivity under mild reaction conditions. Structural divergence is observed as either haloalkylated or haloalkenylated products are formed based on substitution pattern of the siloxydiene. The halogenated products show utility in further synthetic transformations selec- tive reduction and cross coupling reactions.
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