杏仁核和海马中的 AMP 激活蛋白激酶有助于增强糖尿病小鼠的恐惧记忆力

IF 6.8 2区医学 Q1 PHARMACOLOGY & PHARMACY

British Journal of Pharmacology Pub Date : 2024-09-18 DOI:10.1111/bph.17338

Aimi Yamagishi, Naomi Yonemochi, Ai Kimura, Fumiko Takenoya, Seiji Shioda, John L. Waddington, Hiroko Ikeda

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引用次数: 0

摘要

糖尿病患者患精神疾病的风险增加。由于高血糖会增加大脑中的左旋乳酸，而左旋乳酸会抑制 AMP 激活蛋白激酶（AMPK），因此本研究调查了左旋乳酸和 AMPK 在糖尿病小鼠强化恐惧记忆（一种人类精神疾病模型）中的作用。

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AMP-activated protein kinase in the amygdala and hippocampus contributes to enhanced fear memory in diabetic mice

Diabetic patients have an increased risk of psychiatric disorders. Because hyperglycaemia increases L-lactate in the brain and L-lactate inhibits AMP-activated protein kinase (AMPK), this study investigated the role of L-lactate and AMPK in strengthened fear memory, a model for human psychiatric disorders, in diabetic mice.

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来源期刊

British Journal of Pharmacology 医学-药学

CiteScore

15.40

自引率

12.30%

发文量

270

审稿时长

2.0 months

期刊介绍： The British Journal of Pharmacology (BJP) is a biomedical science journal offering comprehensive international coverage of experimental and translational pharmacology. It publishes original research, authoritative reviews, mini reviews, systematic reviews, meta-analyses, databases, letters to the Editor, and commentaries. Review articles, databases, systematic reviews, and meta-analyses are typically commissioned, but unsolicited contributions are also considered, either as standalone papers or part of themed issues. In addition to basic science research, BJP features translational pharmacology research, including proof-of-concept and early mechanistic studies in humans. While it generally does not publish first-in-man phase I studies or phase IIb, III, or IV studies, exceptions may be made under certain circumstances, particularly if results are combined with preclinical studies.