猪急性心肌梗死模型中的心脏保护性微RNA（protectomiRs）以及缺血调理对心脏的保护作用：MiR-450a

IF 6.8 2区医学 Q1 PHARMACOLOGY & PHARMACY

British Journal of Pharmacology Pub Date : 2024-09-18 DOI:10.1111/bph.17313

Regina N. Nagy, András Makkos, Tamás Baranyai, Zoltán Giricz, Márta Szabó, Bernadett Kravcsenko-Kiss, Zoltán Bereczki, Bence Ágg, László G. Puskás, Nóra Faragó, Rainer Schulz, Mariann Gyöngyösi, Dominika Lukovic, Zoltán V. Varga, Anikó Görbe, Péter Ferdinandy

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引用次数: 0

摘要

心脏保护性 miRNA（protectomiRs）是很有前景的治疗工具。在这里，我们的目的是在急性心肌梗死（AMI）转化猪模型中鉴定保护性 miRNA，并验证它们对心肌细胞的保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cardioprotective microRNAs (protectomiRs) in a pig model of acute myocardial infarction and cardioprotection by ischaemic conditioning: MiR-450a

Cardioprotective miRNAs (protectomiRs) are promising therapeutic tools. Here, we aimed to identify protectomiRs in a translational porcine model of acute myocardial infarction (AMI) and to validate their cardiocytoprotective effect.

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来源期刊

British Journal of Pharmacology 医学-药学

CiteScore

15.40

自引率

12.30%

发文量

270

审稿时长

2.0 months

期刊介绍： The British Journal of Pharmacology (BJP) is a biomedical science journal offering comprehensive international coverage of experimental and translational pharmacology. It publishes original research, authoritative reviews, mini reviews, systematic reviews, meta-analyses, databases, letters to the Editor, and commentaries. Review articles, databases, systematic reviews, and meta-analyses are typically commissioned, but unsolicited contributions are also considered, either as standalone papers or part of themed issues. In addition to basic science research, BJP features translational pharmacology research, including proof-of-concept and early mechanistic studies in humans. While it generally does not publish first-in-man phase I studies or phase IIb, III, or IV studies, exceptions may be made under certain circumstances, particularly if results are combined with preclinical studies.