miR-133b 是阿尔茨海默病突触 NPTX2 蛋白的潜在调节因子

IF 4.4 2区医学 Q1 CLINICAL NEUROLOGY

Annals of Clinical and Translational Neurology Pub Date : 2024-09-17 DOI:10.1002/acn3.52175

Sang-Won Han, Young Ho Park, Paula J Bice, David A. Bennett, SangYun Kim, Andrew J. Saykin, Kwangsik Nho

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引用次数: 0

摘要

一种突触蛋白--神经元五肽 2（NPTX2）已成为阿尔茨海默氏症痴呆症（AD）的关键生物标志物。我们确定了靶向 NPTX2 的候选 miRNA，并利用多组学数据（N = 702）进行了关联和中介分析。在 44 个候选 miRNA 中，miR-133b 与 AD 和 Braak 阳性有显著相关性。较高的 miR-133b 表达量也与较高的 NPTX2 基因表达量和较好的认知能力有关。中介分析表明，miR-133b 通过 NPTX2 蛋白对注意力缺失症和认知能力产生部分影响。我们的综合方法表明了 miR-133b 在突触完整性中的潜在作用，并为了解 AD 发病机制提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

miR-133b as a potential regulator of a synaptic NPTX2 protein in Alzheimer's disease

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miR-133b as a potential regulator of a synaptic NPTX2 protein in Alzheimer's disease

A synaptic protein, Neuronal Pentraxin 2 (NPTX2), has emerged as a pivotal biomarker for Alzheimer's dementia (AD). We identified candidate miRNAs targeting NPTX2 and performed association and mediation analyses using multi-omics data (N = 702). Among 44 candidate miRNAs, miR-133b was significantly associated with AD and Braak positivity. Higher miR-133b expression was also associated with higher NPTX2 gene expression and better cognition. Mediation analysis showed that miR-133b partially influences AD and cognition through the NPTX2 protein. Our integrated approach suggests a potential role of miR-133b in synaptic integrity and offers new insights into AD pathogenesis.

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来源期刊

Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)

CiteScore

9.10

自引率

1.90%

发文量

218

审稿时长

8 weeks

期刊介绍： Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.