开角型青光眼患者接受 SDM 激光视力保护疗法后视网膜神经纤维和神经节细胞复合层逐渐增厚

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2024-09-19 DOI:10.1007/s40123-024-01029-3

Jeffrey K. Luttrull, Radouil Tzekov, Sathy V. Bhavan

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引用次数: 0

摘要

方法对光谱域光学相干断层扫描 (OCT) 测得的神经纤维层 (NFL) 和神经节细胞复合体 (GCC) 厚度趋势进行回顾性分析，排除扫描质量差和主要诊断为 OAG 以外的眼。本研究比较了仅通过控制眼压进行常规治疗的 OAG 患眼（对照组）和通过加用 VPT 进行治疗的患眼（VPT 患眼）。OCT趋势的方向（+或-）和幅度（微米/年）是研究的终点。结果研究纳入了 40 名患者的 78 只对照眼和 39 名患者的 61 只接受过 VPT 治疗的眼。5%的对照眼和 71% 的 VPT 治疗眼出现了 NFL 阳性趋势（p < 0.0001）。8%的对照组眼球与 43% 的 VPT 眼球相比，GCC 呈阳性趋势（p < 0.0001）。对照组的平均 NFL 趋势（µm/年）为 - 0.692，而 VPT 为 0.347（p < 0.0001）。结论在 OAG 的常规治疗中加入 VPT，可显著改善 NFL 和 GCC 的趋势，表明青光眼严重程度和进展的关键指标发生了逆转。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Progressive Thickening of Retinal Nerve Fiber and Ganglion Cell Complex Layers Following SDM Laser Vision Protection Therapy in Open-Angle Glaucoma

查看原文本刊更多论文

Progressive Thickening of Retinal Nerve Fiber and Ganglion Cell Complex Layers Following SDM Laser Vision Protection Therapy in Open-Angle Glaucoma

Introduction

This work aims to determine the effect on nerve fiber layer (NFL) and ganglion cell complex (GCC) thickness trends in eyes with open-angle glaucoma (OAG) treated with Vision Protection Therapy™ (VPT).

Methods

A retrospective analysis of spectral-domain optical coherence tomography (OCT) measured NFL and GCC thickness trends was performed, excluding eyes with poor-quality scans and principal diagnoses other than OAG. This study compares eyes with OAG managed conventionally with IOP control alone (controls) to eyes managed with the addition of VPT (VPT eyes). The direction (+ or −) and magnitude (microns/year) of the OCT trends were the study endpoints.

Results

Seventy-eight control eyes of 40 patients and 61 VPT-treated eyes of 39 patients were included in the study. Positive NFL trends were noted in 5% of control eyes vs. 71% of VPT eyes (p < 0.0001). Positive GCC trends were noted in 8% of control eyes vs. 43% of VPT eyes (p < 0.0001). Mean NFL trends (µm/year) were − 0.692 for controls vs. 0.347 for VPT (p < 0.0001). Mean GCC trends (µm/year) were − 0.554 for controls vs. − 0.148 for VPT (p = 0.0175).

Conclusions

The addition of VPT to the conventional management of OAG resulted in highly significant improvements in NFL and GCC trends, indicating a reversal of key indicators of glaucoma severity and progression.

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. Rapid Publication The journal’s publication timelines aim for a rapid peer review of 2 weeks. If an article is accepted it will be published 3–4 weeks from acceptance. The rapid timelines are achieved through the combination of a dedicated in-house editorial team, who manage article workflow, and an extensive Editorial and Advisory Board who assist with peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. Combined with the journal’s open access model this allows for the rapid, efficient communication of the latest research and reviews, fostering the advancement of ophthalmic therapies. Open Access All articles published by Ophthalmology and Therapy are open access. 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