Linh Dieu Nguyen, Khanh Ha Nguyen, Phat Ngoc Nguyen, Kim Nguyen Tran, Diep Dinh Le, Phuong Hoang Tran, Hai Truong Nguyen
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{"title":"使用稻壳衍生碳质磺化物作为绿色催化剂合成吲哚基 1H 吡咯的环保方法","authors":"Linh Dieu Nguyen, Khanh Ha Nguyen, Phat Ngoc Nguyen, Kim Nguyen Tran, Diep Dinh Le, Phuong Hoang Tran, Hai Truong Nguyen","doi":"10.1002/jctb.7758","DOIUrl":null,"url":null,"abstract":"BACKGROUNDAmorphous carbon‐bearing sulfonic acid groups (AC–SO<jats:sub>3</jats:sub>H) are a kind of solid acid that exhibits high acidity and belongs to the new generation of solid acids. The presence of acidic functional groups, including carboxylic acid, phenolic and sulfonic acid groups, allows for several key activities such as strong Brønsted acid properties, high surface area, stability, reusability and recyclability.RESULTSIn this work, we synthesized indolyl 1<jats:italic>H</jats:italic>‐pyrroles from indoles, phenylglyoxal monohydrate, 1,3‐diketones and ammonium acetate using rice‐husk‐derived carbonaceous sulfonation (AC–SO<jats:sub>3</jats:sub>H) as a catalyst. We explored the impact of catalyst quantity, reaction time, solvent, mineral acid and temperature in order to determine the optimal reaction conditions. Additionally, indolyl 1<jats:italic>H</jats:italic>‐pyrrole derivatives were also synthesized based on the optimal conditions that were completely investigated, and the structure of these synthetic compounds was characterized by <jats:sup>1</jats:sup>H‐ and <jats:sup>13</jats:sup>C‐nuclear magnetic resonance.CONCLUSIONThe yield of indolyl 1<jats:italic>H</jats:italic>‐pyrroles was up to 84% in 6 h at 100 °C with the activity of 30 mg AC–SO<jats:sub>3</jats:sub>H. Besides, based on the optimal conditions, 21 indolyl 1<jats:italic>H</jats:italic>‐pyrrole derivatives were formed with the high‐yield and green method. The catalyst could be reused multiple times without a significant decrease in catalytic performance. According to the findings from the experiments, a potential mechanism that included a radical process has been suggested. This eco‐friendly approach provided a straightforward and efficient method to produce a variety of indole–pyrrole conjugates in a single step. © 2024 Society of Chemical Industry (SCI).","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Eco‐friendly approaches for synthesis of indolyl 1H‐pyrroles using rice‐husk‐derived carbonaceous sulfonation as the green catalyst\",\"authors\":\"Linh Dieu Nguyen, Khanh Ha Nguyen, Phat Ngoc Nguyen, Kim Nguyen Tran, Diep Dinh Le, Phuong Hoang Tran, Hai Truong Nguyen\",\"doi\":\"10.1002/jctb.7758\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"BACKGROUNDAmorphous carbon‐bearing sulfonic acid groups (AC–SO<jats:sub>3</jats:sub>H) are a kind of solid acid that exhibits high acidity and belongs to the new generation of solid acids. The presence of acidic functional groups, including carboxylic acid, phenolic and sulfonic acid groups, allows for several key activities such as strong Brønsted acid properties, high surface area, stability, reusability and recyclability.RESULTSIn this work, we synthesized indolyl 1<jats:italic>H</jats:italic>‐pyrroles from indoles, phenylglyoxal monohydrate, 1,3‐diketones and ammonium acetate using rice‐husk‐derived carbonaceous sulfonation (AC–SO<jats:sub>3</jats:sub>H) as a catalyst. We explored the impact of catalyst quantity, reaction time, solvent, mineral acid and temperature in order to determine the optimal reaction conditions. Additionally, indolyl 1<jats:italic>H</jats:italic>‐pyrrole derivatives were also synthesized based on the optimal conditions that were completely investigated, and the structure of these synthetic compounds was characterized by <jats:sup>1</jats:sup>H‐ and <jats:sup>13</jats:sup>C‐nuclear magnetic resonance.CONCLUSIONThe yield of indolyl 1<jats:italic>H</jats:italic>‐pyrroles was up to 84% in 6 h at 100 °C with the activity of 30 mg AC–SO<jats:sub>3</jats:sub>H. Besides, based on the optimal conditions, 21 indolyl 1<jats:italic>H</jats:italic>‐pyrrole derivatives were formed with the high‐yield and green method. The catalyst could be reused multiple times without a significant decrease in catalytic performance. According to the findings from the experiments, a potential mechanism that included a radical process has been suggested. This eco‐friendly approach provided a straightforward and efficient method to produce a variety of indole–pyrrole conjugates in a single step. © 2024 Society of Chemical Industry (SCI).\",\"PeriodicalId\":15335,\"journal\":{\"name\":\"Journal of chemical technology and biotechnology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of chemical technology and biotechnology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1002/jctb.7758\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of chemical technology and biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1002/jctb.7758","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
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Eco‐friendly approaches for synthesis of indolyl 1H‐pyrroles using rice‐husk‐derived carbonaceous sulfonation as the green catalyst
BACKGROUNDAmorphous carbon‐bearing sulfonic acid groups (AC–SO3 H) are a kind of solid acid that exhibits high acidity and belongs to the new generation of solid acids. The presence of acidic functional groups, including carboxylic acid, phenolic and sulfonic acid groups, allows for several key activities such as strong Brønsted acid properties, high surface area, stability, reusability and recyclability.RESULTSIn this work, we synthesized indolyl 1H ‐pyrroles from indoles, phenylglyoxal monohydrate, 1,3‐diketones and ammonium acetate using rice‐husk‐derived carbonaceous sulfonation (AC–SO3 H) as a catalyst. We explored the impact of catalyst quantity, reaction time, solvent, mineral acid and temperature in order to determine the optimal reaction conditions. Additionally, indolyl 1H ‐pyrrole derivatives were also synthesized based on the optimal conditions that were completely investigated, and the structure of these synthetic compounds was characterized by 1 H‐ and 13 C‐nuclear magnetic resonance.CONCLUSIONThe yield of indolyl 1H ‐pyrroles was up to 84% in 6 h at 100 °C with the activity of 30 mg AC–SO3 H. Besides, based on the optimal conditions, 21 indolyl 1H ‐pyrrole derivatives were formed with the high‐yield and green method. The catalyst could be reused multiple times without a significant decrease in catalytic performance. According to the findings from the experiments, a potential mechanism that included a radical process has been suggested. This eco‐friendly approach provided a straightforward and efficient method to produce a variety of indole–pyrrole conjugates in a single step. © 2024 Society of Chemical Industry (SCI).