身体质量指数的性别特异性孟德尔随机化-全基因组关联研究

medRxiv - Epidemiology Pub Date : 2024-09-13 DOI:10.1101/2024.09.12.24313524

Zhu Liduzi Jiesisibieke, Io Ieong Chan, Jack Chun Man Ng, C Mary Schooling

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引用次数: 0

摘要

背景：有关增量蛋白的试验越来越清楚地表明，体重指数（BMI）与人一生中的多种疾病有关，但这些试验无法全面评估 BMI 在男性和女性健康相关属性中的作用。为了系统地研究 BMI 的作用，我们进行了一项性别特异性孟德尔随机全表型关联研究。

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A Sex-specific Mendelian Randomization-Phenome-Wide Association Study of Body Mass Index

Background: Trials of incretins are making it increasingly clear that body mass index (BMI) is linked to several diseases throughout life, but trials cannot provide a comprehensive assessment of the role of BMI in health-related attributes for men and women. To systematically investigate the role of BMI, we conducted a sex-specific Mendelian randomization-phenome-wide association study.

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medRxiv - Epidemiology

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