METTL 蛋白家族：关注癌症的发生、发展和治疗

IF 9.5 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarker Research Pub Date : 2024-09-17 DOI:10.1186/s40364-024-00652-3

Huhu Zhang, Fulin Sun, Shuyao Jiang, Fanghao Yang, Xiaolei Dong, Guoxiang Liu, Mengjun Wang, Ya Li, Mohan Su, Ziyuan Wen, Chunjuan Yu, Chenkai Fan, Xiaoxia Li, Zhe Zhang, Lina Yang, Bing Li

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引用次数: 0

摘要

甲基转移酶样蛋白是人体内一种无处不在的酶样蛋白，具有核酸、蛋白质和其他小分子的结合域，在正常生物和疾病的多种生物学行为中发挥着重要作用，其特点是存在一个甲基转移酶样结构域和一个结构保守的SAM结合域，该结合域由蛋白中心的七链β折叠结构形成。随着研究的深入，发现METTL蛋白家族在多种肿瘤疾病中异常表达，明确其与肿瘤疾病的关系可作为分子治疗靶点，对肿瘤的预后具有重要作用。本文综述了METTL蛋白家族的结构、生物学过程、免疫治疗、药物靶向治疗和标记物等，为肿瘤的诊断和治疗提供新思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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METTL protein family: focusing on the occurrence, progression and treatment of cancer

Methyltransferase-like protein is a ubiquitous enzyme-like protein in the human body, with binding domains for nucleic acids, proteins and other small molecules, and plays an important role in a variety of biological behaviours in normal organisms and diseases, characterised by the presence of a methyltransferase-like structural domain and a structurally conserved SAM-binding domain formed by the seven-stranded β-fold structure in the center of the protein. With the deepening of research, the METTL protein family has been found to be abnormally expressed in a variety of tumor diseases, and the clarification of its relationship with tumor diseases can be used as a molecular therapeutic target and has an important role in the prognosis of tumors. In this paper, we review the structure, biological process, immunotherapy, drug-targeted therapy, and markers of the METTL protein family to provide new ideas for the diagnosis and treatment of tumors.

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来源期刊

Biomarker Research Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

15.80

自引率

1.80%

发文量

审稿时长

10 weeks

期刊介绍： Biomarker Research, an open-access, peer-reviewed journal, covers all aspects of biomarker investigation. It seeks to publish original discoveries, novel concepts, commentaries, and reviews across various biomedical disciplines. The field of biomarker research has progressed significantly with the rise of personalized medicine and individual health. Biomarkers play a crucial role in drug discovery and development, as well as in disease diagnosis, treatment, prognosis, and prevention, particularly in the genome era.