中国 6-18 岁健康儿童呼出一氧化氮的参考值：一项横断面多中心临床研究

IF 4.7 2区医学 Q1 RESPIRATORY SYSTEM

Respiratory Research Pub Date : 2024-09-16 DOI:10.1186/s12931-024-02938-4

Yazun Liu, Hao Zhang, Jinrong Wang, Yuling Han, Chunhong Pan, Wenhui Jiang, Chunyan Ma, Yongsheng Shi, Chunmei Jia, Yuehua Zhang, Ming Li, Fei Wang, Yanyan Yu, Yong Feng, Li Liu, Aihong Liu, Qiaoling Zhang, Zhen Long, Fuli Dai, Yanli Zhang, Minghong Ji, Dongjun Ma

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引用次数: 0

摘要

不同国家、不同种族人群的电子鼻参考值存在一定差异。我们旨在获得中国健康儿童和青少年（6-18 岁）的 eNO 参考值，并探讨参考值与年龄、性别、身高、体重指数和地区之间的关联。我们测量了 5949 名中国健康儿童和青少年的 FeNO50 水平，以及来自中国 7 个行政区 16 个省份 658 名 6-18 岁儿童和青少年的 FeNO200 和 CaNO 水平。所有研究人员均在征得儿童及其家长的知情同意后进行。5949 名 6-18 岁中国儿童和青少年的 FeNO50 平均值为 14.1 ppb，95% 置信区间为 1-38.1 ppb。658 人的 FeNO200 平均值为 6.9 ppb，95% 置信区间上限为 15.0 ppb；CaNO 平均值为 3.0 ppb，95% 置信区间上限为 11.2 ppb。在 6-11 岁年龄组中，年龄和身高与 FeNO50 的对数相关（P 0.05）。CaNO 的对数与性别相关（P < 0.05）。在 12-18 岁年龄组中，性别、身高和地区与 FeNO50 的对数相关（均 P <0.001）。FeNO200 的对数与身高之间只有微弱的相关性（P < 0.001）。CaNO 的对数与年龄呈负相关（P < 0.05）。与国外报道相比，中国健康儿童和青少年的 FeNO50、FeNO200 和 CaNO 值较高，且受年龄、身高、性别和地区的影响。本研究为电子鼻在儿童尤其是亚洲儿童中的临床应用提供了有益的参考。

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Reference values for exhaled nitric oxide in healthy children aged 6–18 years in China: a cross-sectional, multicenter clinical study

The reference values of eNO have certain differences among people of different countries and races. We aimed to obtain the reference value of eNO in healthy children and adolescents (6–18 years old) in China and to explore the associations between the reference values with ages, gender, heights, BMI, and regions. We measured FeNO50 levels in 5949 healthy Chinese children and adolescents, FeNO200 and CaNO levels in 658 participants from 16 provinces of 7 administrative areas in China aged 6–18. All persons were studied after obtaining informed consent from children and their parents. The mean FeNO50 of 5949 Chinese children and adolescents aged 6–18 years was 14.1 ppb, with a 95% confidence interval of 1-38.1 ppb. The mean FeNO200 of 658 persons was 6.9 ppb with a 95% upper confidence interval of 15.0 ppb, and the mean CaNO was 3.0 ppb with a 95% upper confidence interval of 11.2 ppb. In the 6–11 age group, age and height were correlated with the logarithm of FeNO50 (P < 0.001, P < 0.05). There was no significant correlation between the logarithm of FeNO200 and gender, age, height and BMI (all P > 0.05). The logarithm of CaNO was correlated with gender (P < 0.05). In the 12–18 age group, gender, height, and region were correlated with the logarithm of FeNO50 (all P < 0.001). There was only a weak correlation between the logarithm of FeNO200 and height (P < 0.001). The logarithm of CaNO was negatively correlated with age (P < 0.05). Higher FeNO50, FeNO200 and CaNO values were found in healthy children and adolescents in China compared with foreign reports, and is affected by age, height, gender, and region. This study provides useful references for clinical application of eNO in children, especially Asian children.

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来源期刊

Respiratory Research 医学-呼吸系统

自引率

1.70%

发文量

314

期刊介绍： Respiratory Research publishes high-quality clinical and basic research, review and commentary articles on all aspects of respiratory medicine and related diseases. As the leading fully open access journal in the field, Respiratory Research provides an essential resource for pulmonologists, allergists, immunologists and other physicians, researchers, healthcare workers and medical students with worldwide dissemination of articles resulting in high visibility and generating international discussion. Topics of specific interest include asthma, chronic obstructive pulmonary disease, cystic fibrosis, genetics, infectious diseases, interstitial lung diseases, lung development, lung tumors, occupational and environmental factors, pulmonary circulation, pulmonary pharmacology and therapeutics, respiratory immunology, respiratory physiology, and sleep-related respiratory problems.