黄连总黄酮对骨代谢生化指标的影响：系统综述和荟萃分析

IF 4.4 2区医学 Q1 PHARMACOLOGY & PHARMACY

Frontiers in Pharmacology Pub Date : 2024-09-18 DOI:10.3389/fphar.2024.1443235

Wei Li, Zechen Zhang, Yuyi Li, Zhenyu Wu, Chengjie Wang, Zhen Huang, Baisheng Ye, Xin Jiang, Xiaolong Yang, Xiaolin Shi

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引用次数: 0

摘要

背景有证据表明，黄连总黄酮（TFRD）可以改善骨矿物质密度（BMD）。方法检索PubMed、Web of Science、Cochrane Library、Embase、中国国家知识基础设施（CNKI）、万方数据库、重庆VIP信息库（VIP）和SinoMed，检索时间从开始到2024年5月6日。结果最终纳入了9项随机对照试验（RCT）。与其他疗法相比，TFRD组的骨胶原蛋白（BGP）和I型胶原蛋白-N-丙肽（PINP）含量更高（WMD：5.11；95% CI：3.37，6.84；p&;lt; 0.00001；WMD：13.89；95% CI：11.81，15.97；p&;lt; 0.00001）。耐酒石酸磷酸酶（TRACP）显著下降（WMD：-1.34；95% CI：-1.62，-1.06；p < 0.00001）。碱性磷酸酶（ALP）明显升高（WMD：7.47；95% CI：6.29，8.66；pamp &;lt; 0.00001）。TFRD组与对照组的血清钙（SC）或血清磷（SP）水平无明显差异（WMD：0.08；95% CI：-0.04，0.20；p = 0.17；WMD：0.02；95% CI：-0.02，0.05；p = 0.36）。结论TFRD可刺激骨质疏松症（OP）患者的骨形成并防止骨吸收，但对SC和SP无影响。系统综述注册https://www.crd.york.ac.uk/PROSPERO/。

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Effects of total flavonoids of Rhizoma Drynariae on biochemical indicators of bone metabolism: a systematic review and meta-analysis

BackgroundEvidence shows that the total flavonoids of Rhizoma Drynariae (TFRD) can improve bone mineral density (BMD). However, there is no evidence to summarize the improvement of biochemical indicators of bone metabolism (BIBM).MethodsThe PubMed, Web of Science, Cochrane Library, Embase, Chinese National Knowledge Infrastructure (CNKI), Wanfang Database, Chongqing VIP Information Database (VIP) and SinoMed were searched from inception to 6 May 2024. The final included studies performed meta-analyses using RevMan 5.3.ResultsNine randomized controlled trials (RCTs) were ultimately included. The TFRD group had higher bone gla protein (BGP) and type I procollagen-N-propeptide (PINP) compared to the Other therapies (WMD: 5.11; 95% CI: 3.37, 6.84; p < 0.00001; WMD: 13.89; 95% CI: 11.81, 15.97; p < 0.00001). The tartrate-resistant acid phosphatase (TRACP) decreased significantly (WMD: −1.34; 95% CI: −1.62, −1.06; p < 0.00001). The alkaline phosphatase (ALP) increased significantly (WMD: 7.47; 95% CI: 6.29, 8.66; p < 0.00001). There were no significant differences in serum calcium (SC) or serum phosphorus (SP) levels between the TFRD and control groups (WMD: 0.08; 95% CI: −0.04, 0.20; p = 0.17; WMD: 0.02; 95% CI: −0.02, 0.05; p = 0.36).ConclusionTFRD can stimulate bone formation and prevent bone resorption in osteoporosis (OP) patients, but it has no effect on SC and SP.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/.

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来源期刊

Frontiers in Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

7.80

自引率

8.90%

发文量

5163

审稿时长

14 weeks

期刊介绍： Frontiers in Pharmacology is a leading journal in its field, publishing rigorously peer-reviewed research across disciplines, including basic and clinical pharmacology, medicinal chemistry, pharmacy and toxicology. Field Chief Editor Heike Wulff at UC Davis is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.