Kerry M. Sheets MD, MS, Allyson M. Kats MS, Howard A. Fink MD, MPH, Lisa Langsetmo PhD, Kristine Yaffe MD, Kristine E. Ensrud MD, MPH
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The primary outcome was adjudicated CI defined as mild cognitive impairment or dementia; scores on a 6-test cognitive battery were secondary outcomes.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Compared to women with life-space scores of 81–120 and after adjustment for demographics and depressive symptoms, the odds of CI was 1.4-fold (OR 1.36, 95% CI 0.91–2.03) higher for women with life-space scores of 61–80, twofold (OR 1.98, 95% CI 1.33–2.94) higher for women with life-space scores of 41–60, 2.6-fold (OR 2.62, 95% CI 1.71–4.01) higher for women with life-space scores of 21–40, and 2.7-fold (OR 2.71, 95% CI 1.27–5.79) higher for women with life-space scores of 0–20. The association of life-space scores with adjudicated CI was primarily due to higher odds of dementia; the odds of dementia versus normal cognition was eightfold (OR 8.63, 95% CI 3.20–23.26) higher among women with life-space scores of 0–20 compared to women with life-space scores of 81–120. Lower life-space scores were associated in a graded manner with lower mean scores on tests of delayed recall (California Verbal Learning Test-II delayed recall) and language and executive function (phonemic fluency, category fluency, and Trails B). Life-space score was not associated with scores on tests of attention and working memory (forward and backward digit span).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Lower life-space mobility is associated in a graded manner with CI among community-dwelling White women in the 9th and 10th decades of life.</p>\n </section>\n </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 1","pages":"206-213"},"PeriodicalIF":4.3000,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgs.19190","citationCount":"0","resultStr":"{\"title\":\"Life-space mobility and cognition in community-dwelling late-life women: A cross-sectional analysis\",\"authors\":\"Kerry M. Sheets MD, MS, Allyson M. Kats MS, Howard A. Fink MD, MPH, Lisa Langsetmo PhD, Kristine Yaffe MD, Kristine E. 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引用次数: 0
摘要
背景生活空间的流动性反映了老年人的日常活动能力。我们测定了社区居住的九十岁和十十岁女性的生活空间流动性与认知障碍（CI）之间的横断面关联。方法共有 1375 名（平均年龄 88 岁；88% 白人）社区居住的女性加入了老年女性前瞻性队列。生活空间得分的计算范围为 0（每天仅限于自己的卧室）至 120（每天出城旅行无需他人协助），并分为 0-20、21-40、41-60、61-80、81-120 分。结果与生活空间评分为 81-120 分的女性相比，在对人口统计学和抑郁症状进行调整后，生活空间评分为 81-120 分的女性患 CI 的几率是生活空间评分为 81-120 分女性的 1.4 倍（OR 1.36，95% CI 0.91-2.03）。生命空间分数为 61-80 分的女性的几率要高出 1.4 倍（OR 1.36，95% CI 0.91-2.03），生命空间分数为 41-60 分的女性的几率要高出 2 倍（OR 1.98，95% CI 1.33-2.94），生命空间分数为 21-40 分的女性的几率要高出 2.6 倍（OR 2.62，95% CI 1.71-4.01），生命空间分数为 0-20 分的女性的几率要高出 2.7 倍（OR 2.71，95% CI 1.27-5.79）。生命空间得分与判定的 CI 的关系主要是由于痴呆的几率更高；与生命空间得分 81-120 分的女性相比，生命空间得分 0-20 分的女性痴呆的几率是正常认知的 8 倍（OR 8.63，95% CI 3.20-23.26）。生命空间分数较低与延迟回忆测试（加利福尼亚言语学习测试-II延迟回忆）以及语言和执行功能测试（语音流畅性、类别流畅性和Trails B）的平均分数较低呈分级关系。结论在社区居住的白人妇女中，生命期第 9 和第 10 个十年的生命空间活动度较低与 CI 呈分级关系。
Life-space mobility and cognition in community-dwelling late-life women: A cross-sectional analysis
Background
Life-space mobility captures the daily, enacted mobility of older adults. We determined cross-sectional associations between life-space mobility and cognitive impairment (CI) among community-dwelling women in the 9th and 10th decades of life.
Methods
A total of 1375 (mean age 88 years; 88% White) community-dwelling women enrolled in a prospective cohort of older women. Life-space score was calculated with range 0 (daily restriction to one's bedroom) to 120 (daily trips leaving town without assistance) and categorized (0–20, 21–40, 41–60, 61–80, 81–120). The primary outcome was adjudicated CI defined as mild cognitive impairment or dementia; scores on a 6-test cognitive battery were secondary outcomes.
Results
Compared to women with life-space scores of 81–120 and after adjustment for demographics and depressive symptoms, the odds of CI was 1.4-fold (OR 1.36, 95% CI 0.91–2.03) higher for women with life-space scores of 61–80, twofold (OR 1.98, 95% CI 1.33–2.94) higher for women with life-space scores of 41–60, 2.6-fold (OR 2.62, 95% CI 1.71–4.01) higher for women with life-space scores of 21–40, and 2.7-fold (OR 2.71, 95% CI 1.27–5.79) higher for women with life-space scores of 0–20. The association of life-space scores with adjudicated CI was primarily due to higher odds of dementia; the odds of dementia versus normal cognition was eightfold (OR 8.63, 95% CI 3.20–23.26) higher among women with life-space scores of 0–20 compared to women with life-space scores of 81–120. Lower life-space scores were associated in a graded manner with lower mean scores on tests of delayed recall (California Verbal Learning Test-II delayed recall) and language and executive function (phonemic fluency, category fluency, and Trails B). Life-space score was not associated with scores on tests of attention and working memory (forward and backward digit span).
Conclusions
Lower life-space mobility is associated in a graded manner with CI among community-dwelling White women in the 9th and 10th decades of life.
期刊介绍：
Journal of the American Geriatrics Society (JAGS) is the go-to journal for clinical aging research. We provide a diverse, interprofessional community of healthcare professionals with the latest insights on geriatrics education, clinical practice, and public policy—all supporting the high-quality, person-centered care essential to our well-being as we age. Since the publication of our first edition in 1953, JAGS has remained one of the oldest and most impactful journals dedicated exclusively to gerontology and geriatrics.
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