为肾脏交换变体设计无数据神经网络

Sangram K. Jena, K. Subramani, Alvaro Velasquez
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摘要

肾移植对于治疗终末期肾病至关重要,大约每一千名欧洲人中就有一人受到影响。寻找合适的死亡捐献者往往会导致漫长而不确定的等待时间,因此活体捐献者移植成为一种可行的替代方案。然而,约有 40% 的活体捐献者与预期受体不相容。因此,许多国家制定了肾脏交换计划,允许供体不相容的患者参与 "交换 "安排,与其他情况类似的患者交换供体。顶点二交循环覆盖问题的几个变体对上述问题进行了建模,根据需要处理肾脏交换的不同方面。本文讨论了几种具体的顶点相交循环覆盖变体,并探讨了如何找到精确的解决方案。我们采用无数据神经网络框架,为每个变体建立了单可变函数。最近的研究强调了该框架在表示若干组合优化问题时的有效性。受这些研究成果的启发,我们提出了针对顶点二交循环覆盖变体的定制无数据神经网络。我们为每个变体推导出一个可微分函数,并证明如果找到相应问题变体的精确解,该函数将达到其最小值。我们还证明了我们方法的正确性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Designing dataless neural networks for kidney exchange variants

Designing dataless neural networks for kidney exchange variants

Kidney transplantation is vital for treating end-stage renal disease, impacting roughly one in a thousand Europeans. The search for a suitable deceased donor often leads to prolonged and uncertain wait times, making living donor transplants a viable alternative. However, approximately 40% of living donors are incompatible with their intended recipients. Therefore, many countries have established kidney exchange programs, allowing patients with incompatible donors to participate in “swap” arrangements, exchanging donors with other patients in similar situations. Several variants of the vertex-disjoint cycle cover problem model the above problem, which deals with different aspects of kidney exchange as required. This paper discusses several specific vertex-disjoint cycle cover variants and deals with finding the exact solution. We employ the dataless neural networks framework to establish single differentiable functions for each variant. Recent research highlights the framework’s effectiveness in representing several combinatorial optimization problems. Inspired by these findings, we propose customized dataless neural networks for vertex-disjoint cycle cover variants. We derive a differentiable function for each variant and prove that the function will attain its minimum value if an exact solution is found for the corresponding problem variant. We also provide proof of the correctness of our approach.

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