{"title":"短读数纳米孔测序的精确基数调用","authors":"Ziyuan Wang, Mei-Juan Tu, Chengcheng Song, Ziyang Liu, Katherine K Wang, Shuibing Chen, Ai-Ming Yu, HONGXU DING","doi":"10.1101/2024.09.12.612746","DOIUrl":null,"url":null,"abstract":"The nanopore sequencing of short sequences, whose lengths are typically less than 0.3kb therefore comparable with Illumina sequencing techniques, has recently gained wide attention. Here, we design a scheme for training nanopore basecallers that are specialized for short biomolecules. With bioengineered RNA (BioRNA) molecules as examples, we demonstrate the superior accuracy of basecallers trained by our scheme.","PeriodicalId":501307,"journal":{"name":"bioRxiv - Bioinformatics","volume":"15 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Precise Basecalling of Short-Read Nanopore Sequencing\",\"authors\":\"Ziyuan Wang, Mei-Juan Tu, Chengcheng Song, Ziyang Liu, Katherine K Wang, Shuibing Chen, Ai-Ming Yu, HONGXU DING\",\"doi\":\"10.1101/2024.09.12.612746\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The nanopore sequencing of short sequences, whose lengths are typically less than 0.3kb therefore comparable with Illumina sequencing techniques, has recently gained wide attention. Here, we design a scheme for training nanopore basecallers that are specialized for short biomolecules. With bioengineered RNA (BioRNA) molecules as examples, we demonstrate the superior accuracy of basecallers trained by our scheme.\",\"PeriodicalId\":501307,\"journal\":{\"name\":\"bioRxiv - Bioinformatics\",\"volume\":\"15 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"bioRxiv - Bioinformatics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.09.12.612746\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"bioRxiv - Bioinformatics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.12.612746","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Precise Basecalling of Short-Read Nanopore Sequencing
The nanopore sequencing of short sequences, whose lengths are typically less than 0.3kb therefore comparable with Illumina sequencing techniques, has recently gained wide attention. Here, we design a scheme for training nanopore basecallers that are specialized for short biomolecules. With bioengineered RNA (BioRNA) molecules as examples, we demonstrate the superior accuracy of basecallers trained by our scheme.
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