中国 6-9 岁儿童较高的血浆铜暴露量与骨骼肌指标呈负相关:一项横断面研究

IF 3.3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Jie Xu, Jing Lan, Qiaoting Huang, Abubakar Tarawally, Lan Huang, Zheqing Zhang, Gengdong Chen
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引用次数: 0

摘要

目前尚不清楚血液中铜(Cu)、镁(Mg)和钙(Ca)的浓度是否会影响儿童骨骼肌的质量和力量。我们旨在探讨中国儿童血浆中铜、镁和钙与骨骼肌指标之间的关系。这项横断面研究共招募了 452 名 6 至 9 岁的儿童。研究采用双能 X 射线吸收测量法测量了全身瘦软组织质量(WLSTM)、躯干瘦软组织质量(TLSTM)和附属骨骼肌质量(ASMM)。计算出这些指标的参数除以相应部位的身高2(Ht2)和体重(Wt)。此外,还测量了握力。骨骼肌指标和手握力的参数如果低于性别百分位数的 20%,则被视为低水平。使用 ICP-MS 测量了血浆中铜、镁和钙的浓度。在对几个潜在的协变量进行调整后,在所有受试者中,铜浓度每增加一个标准差,WLSTM/Wt 就下降 0.939%,TLSTM/Wt 下降 0.415%,ASMM/Wt 下降 0.47%。铜浓度每增加一个标准差,WLSTM/Wt、TLSTM/Wt(OR:1.33,95%CI 1.03,1.71)、ASMM/Ht2(OR:1.32,95%CI 1.02,1.69)以及 ASMM/Wt (OR:1.56,95%CI 1.23,1.99)偏低的几率就会增加(OR:1.36,95%CI 1.06,1.75)。在镁、钙和大多数骨骼肌指标之间没有发现明显的关联。在中国儿童的多个部位,较高的血浆铜浓度与骨骼肌指标存在不利关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Higher Plasma Copper Exposure was Adversely Associated with Skeletal Muscle Indicators in Chinese Children Aged 6–9 Years: A Cross-Sectional Study

It is unclear whether blood concentrations of copper (Cu), magnesium (Mg), and calcium (Ca) influence skeletal muscle mass and strength in children. We aimed to explore the associations between plasma Cu, Mg, and Ca and skeletal muscle indicators in Chinese children. A total of 452 children aged 6 to 9 years old were recruited for this cross-sectional study. Whole body lean soft tissue mass (WLSTM), trunk lean soft tissue mass (TLSTM), and appendicular skeletal muscle mass (ASMM) were measured using dual-energy X-ray absorptiometry. Parameters of these indicators divided by Height2 (Ht2) and Weight (Wt) at the corresponding sites were calculated. Handgrip strength was also measured. Parameters of skeletal muscle indicators and handgrip strength that were below the sex-specific 20th percentile were considered low levels. Plasma concentrations of Cu, Mg, and Ca were measured using ICP-MS. After adjusting for several potential covariates, among the total subjects, for every one standard deviation increase in Cu concentrations, there was a 0.939% decrease in WLSTM/Wt, a 0.415% decrease in TLSTM/Wt, and a 0.47% decrease in ASMM/Wt. For every one standard deviation increase in Cu concentrations, there was a higher odd (OR: 1.36, 95%CI 1.06, 1.75) of low WLSTM/Wt, TLSTM/Wt (OR: 1.33, 95%CI 1.03, 1.71), ASMM/Ht2 (OR: 1.32, 95%CI 1.02, 1.69), as well as ASMM/Wt (OR: 1.56, 95%CI 1.23, 1.99). No significant associations were found between Mg, Ca, and most skeletal muscle indicators. Higher plasma Cu concentrations were adversely associated with skeletal muscle indicators at multiple sites in Chinese children.

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来源期刊
Calcified Tissue International
Calcified Tissue International 医学-内分泌学与代谢
CiteScore
8.00
自引率
2.40%
发文量
112
审稿时长
4-8 weeks
期刊介绍: Calcified Tissue International and Musculoskeletal Research publishes original research and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms and clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions.
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