在逼真的 CA1 神经元模型中实现海马同步

Alessandro Fiasconaro, Michele Migliore
{"title":"在逼真的 CA1 神经元模型中实现海马同步","authors":"Alessandro Fiasconaro, Michele Migliore","doi":"arxiv-2409.10431","DOIUrl":null,"url":null,"abstract":"This work delves into studying the synchronization in two realistic neuron\nmodels using Hodgkin-Huxley dynamics. Unlike simplistic point-like models,\nexcitatory synapses are here randomly distributed along the dendrites,\nintroducing strong stochastic contributions into their signal propagation. To\nfocus on the role of different excitatory positions, we use two copies of the\nsame neuron whose synapses are located at different distances from the soma and\nare exposed to identical Poissonian distributed current pulses. The\nsynchronization is investigated through a specifically defined spiking\ncorrelation function, and its behavior is analyzed as a function of several\nparameters: inhibition weight, distance from the soma of one synaptic group,\nexcitatory inactivation delay, and weight of the excitatory synapses.","PeriodicalId":501517,"journal":{"name":"arXiv - QuanBio - Neurons and Cognition","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hippocampal synchronization in a realistic CA1 neuron model\",\"authors\":\"Alessandro Fiasconaro, Michele Migliore\",\"doi\":\"arxiv-2409.10431\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This work delves into studying the synchronization in two realistic neuron\\nmodels using Hodgkin-Huxley dynamics. Unlike simplistic point-like models,\\nexcitatory synapses are here randomly distributed along the dendrites,\\nintroducing strong stochastic contributions into their signal propagation. To\\nfocus on the role of different excitatory positions, we use two copies of the\\nsame neuron whose synapses are located at different distances from the soma and\\nare exposed to identical Poissonian distributed current pulses. The\\nsynchronization is investigated through a specifically defined spiking\\ncorrelation function, and its behavior is analyzed as a function of several\\nparameters: inhibition weight, distance from the soma of one synaptic group,\\nexcitatory inactivation delay, and weight of the excitatory synapses.\",\"PeriodicalId\":501517,\"journal\":{\"name\":\"arXiv - QuanBio - Neurons and Cognition\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"arXiv - QuanBio - Neurons and Cognition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/arxiv-2409.10431\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"arXiv - QuanBio - Neurons and Cognition","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/arxiv-2409.10431","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

这项研究利用霍奇金-赫胥黎动力学深入研究了两个现实神经元模型中的同步问题。与简单的点状模型不同,这里的兴奋性突触沿树突随机分布,在信号传播中引入了强烈的随机贡献。为了重点研究不同兴奋位置的作用,我们使用了同一神经元的两个拷贝,它们的突触与体部的距离不同,并暴露在相同的泊松分布电流脉冲下。我们通过一个特别定义的尖峰相关函数来研究这种同步性,并将其行为作为几个参数的函数进行分析:抑制权重、一个突触组距神经元体的距离、兴奋失活延迟和兴奋突触权重。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hippocampal synchronization in a realistic CA1 neuron model
This work delves into studying the synchronization in two realistic neuron models using Hodgkin-Huxley dynamics. Unlike simplistic point-like models, excitatory synapses are here randomly distributed along the dendrites, introducing strong stochastic contributions into their signal propagation. To focus on the role of different excitatory positions, we use two copies of the same neuron whose synapses are located at different distances from the soma and are exposed to identical Poissonian distributed current pulses. The synchronization is investigated through a specifically defined spiking correlation function, and its behavior is analyzed as a function of several parameters: inhibition weight, distance from the soma of one synaptic group, excitatory inactivation delay, and weight of the excitatory synapses.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信