Brendan Portengen, Saskia Imhof, Marnix Naber, Giorgio Porro
{"title":"在标准和虚拟现实观看条件下，瞳孔视力计在检测偏盲方面的诊断性能","authors":"Brendan Portengen, Saskia Imhof, Marnix Naber, Giorgio Porro","doi":"10.1007/s00417-024-06641-4","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>To determine the diagnostic performance and reliability of two pupil perimetry (PP) methods in homonymous hemianopia.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This cross-sectional monocenter cohort study performed gaze-contingent flicker PP (gcFPP) and a virtual reality version of gcFPP (VRgcFPP) twice on separate occasions in all patients suffering from homonymous hemianopia due to neurological impairment. The main outcomes were (1) test accuracy and (2) test–retest reliability: (1) was measured through area under the receiver operating characteristics curve (AUC) calculation of (VR)gcFPP results with comparators being SAP and healthy controls, respectively; (2) was evaluated by comparing tests 1 and 2 of both methods within patients.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Both gcFPP and VRgcFPP were performed in 15 patients (12 males, M<sub>Age</sub> = 57, SD<sub>Age</sub> = 15) and 17 controls (6 males, M<sub>Age</sub> = 53, SD<sub>Age</sub> = 12). Mean test accuracy was good in separating damaged from intact visual field regions (gcFPP: M<sub>auc</sub> = 0.83, SD<sub>auc</sub> = 0.09; VRgcFPP: M<sub>auc</sub> = 0.69, SD<sub>auc</sub> = 0.13) and in separating patients from controls (gcFPP: M<sub>auc</sub> = 0.92, SD<sub>auc</sub> = 0.13; VRgcFPP: M<sub>auc</sub> = 0.96, SD<sub>auc</sub> = 0.15). A high test–retest reliability was found for the proportion intact versus damaged visual field (gcFPP: <i>r</i> = 0.95, <i>P</i> < .001, VRgcFPP: <i>r</i> = 1.00, <i>P</i> < .001).</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Overall, these results can be summarized as follows: (1) the comparison of pupil response amplitudes between intact versus damaged regions per patient indicate that gcFPP allows for cleaner imaging of intact versus damaged visual field regions than VRgcFPP, (2) the comparisons of average differences in intact versus damaged amplitudes between patients and controls demonstrate high diagnostic performance of both gcFPP and VRgcFPP, and (3) the test–retest reliabilities confirm that both gcFPP and VRgcFPP reliably and consistently measure defects in homonymous hemianopia.</p><h3 data-test=\"abstract-sub-heading\">Key messages</h3><p><b><i>What is known</i></b>\n</p><ul>\n<li>\n<p>Standard automated perimetry is the current gold standard for visual field examination, but not always suited for the evaluation of the VF in neurologically impaired patients.</p>\n</li>\n<li>\n<p>Pupil perimetry consists of the measurement of pupillary responses to light stimuli as a measure of visual sensitivity.</p>\n</li>\n</ul><p><b><i>What is new</i></b>\n</p><ul>\n<li>\n<p>This study reports the highest diagnostic accuracy of pupil perimetry so far in patients with homonymous hemianopia.</p>\n</li>\n<li>\n<p>Gaze-contingent flicker pupil perimetry reliably and consistently measures defects in homonymous hemianopia under standard and virtual reality viewing conditions.</p>\n</li>\n</ul>","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"51 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diagnostic performance of pupil perimetry in detecting hemianopia under standard and virtual reality viewing conditions\",\"authors\":\"Brendan Portengen, Saskia Imhof, Marnix Naber, Giorgio Porro\",\"doi\":\"10.1007/s00417-024-06641-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Purpose</h3><p>To determine the diagnostic performance and reliability of two pupil perimetry (PP) methods in homonymous hemianopia.</p><h3 data-test=\\\"abstract-sub-heading\\\">Methods</h3><p>This cross-sectional monocenter cohort study performed gaze-contingent flicker PP (gcFPP) and a virtual reality version of gcFPP (VRgcFPP) twice on separate occasions in all patients suffering from homonymous hemianopia due to neurological impairment. The main outcomes were (1) test accuracy and (2) test–retest reliability: (1) was measured through area under the receiver operating characteristics curve (AUC) calculation of (VR)gcFPP results with comparators being SAP and healthy controls, respectively; (2) was evaluated by comparing tests 1 and 2 of both methods within patients.</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>Both gcFPP and VRgcFPP were performed in 15 patients (12 males, M<sub>Age</sub> = 57, SD<sub>Age</sub> = 15) and 17 controls (6 males, M<sub>Age</sub> = 53, SD<sub>Age</sub> = 12). Mean test accuracy was good in separating damaged from intact visual field regions (gcFPP: M<sub>auc</sub> = 0.83, SD<sub>auc</sub> = 0.09; VRgcFPP: M<sub>auc</sub> = 0.69, SD<sub>auc</sub> = 0.13) and in separating patients from controls (gcFPP: M<sub>auc</sub> = 0.92, SD<sub>auc</sub> = 0.13; VRgcFPP: M<sub>auc</sub> = 0.96, SD<sub>auc</sub> = 0.15). A high test–retest reliability was found for the proportion intact versus damaged visual field (gcFPP: <i>r</i> = 0.95, <i>P</i> < .001, VRgcFPP: <i>r</i> = 1.00, <i>P</i> < .001).</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusions</h3><p>Overall, these results can be summarized as follows: (1) the comparison of pupil response amplitudes between intact versus damaged regions per patient indicate that gcFPP allows for cleaner imaging of intact versus damaged visual field regions than VRgcFPP, (2) the comparisons of average differences in intact versus damaged amplitudes between patients and controls demonstrate high diagnostic performance of both gcFPP and VRgcFPP, and (3) the test–retest reliabilities confirm that both gcFPP and VRgcFPP reliably and consistently measure defects in homonymous hemianopia.</p><h3 data-test=\\\"abstract-sub-heading\\\">Key messages</h3><p><b><i>What is known</i></b>\\n</p><ul>\\n<li>\\n<p>Standard automated perimetry is the current gold standard for visual field examination, but not always suited for the evaluation of the VF in neurologically impaired patients.</p>\\n</li>\\n<li>\\n<p>Pupil perimetry consists of the measurement of pupillary responses to light stimuli as a measure of visual sensitivity.</p>\\n</li>\\n</ul><p><b><i>What is new</i></b>\\n</p><ul>\\n<li>\\n<p>This study reports the highest diagnostic accuracy of pupil perimetry so far in patients with homonymous hemianopia.</p>\\n</li>\\n<li>\\n<p>Gaze-contingent flicker pupil perimetry reliably and consistently measures defects in homonymous hemianopia under standard and virtual reality viewing conditions.</p>\\n</li>\\n</ul>\",\"PeriodicalId\":12748,\"journal\":{\"name\":\"Graefe's Archive for Clinical and Experimental Ophthalmology\",\"volume\":\"51 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Graefe's Archive for Clinical and Experimental Ophthalmology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s00417-024-06641-4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Graefe's Archive for Clinical and Experimental Ophthalmology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00417-024-06641-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Diagnostic performance of pupil perimetry in detecting hemianopia under standard and virtual reality viewing conditions
Purpose
To determine the diagnostic performance and reliability of two pupil perimetry (PP) methods in homonymous hemianopia.
Methods
This cross-sectional monocenter cohort study performed gaze-contingent flicker PP (gcFPP) and a virtual reality version of gcFPP (VRgcFPP) twice on separate occasions in all patients suffering from homonymous hemianopia due to neurological impairment. The main outcomes were (1) test accuracy and (2) test–retest reliability: (1) was measured through area under the receiver operating characteristics curve (AUC) calculation of (VR)gcFPP results with comparators being SAP and healthy controls, respectively; (2) was evaluated by comparing tests 1 and 2 of both methods within patients.
Results
Both gcFPP and VRgcFPP were performed in 15 patients (12 males, MAge = 57, SDAge = 15) and 17 controls (6 males, MAge = 53, SDAge = 12). Mean test accuracy was good in separating damaged from intact visual field regions (gcFPP: Mauc = 0.83, SDauc = 0.09; VRgcFPP: Mauc = 0.69, SDauc = 0.13) and in separating patients from controls (gcFPP: Mauc = 0.92, SDauc = 0.13; VRgcFPP: Mauc = 0.96, SDauc = 0.15). A high test–retest reliability was found for the proportion intact versus damaged visual field (gcFPP: r = 0.95, P < .001, VRgcFPP: r = 1.00, P < .001).
Conclusions
Overall, these results can be summarized as follows: (1) the comparison of pupil response amplitudes between intact versus damaged regions per patient indicate that gcFPP allows for cleaner imaging of intact versus damaged visual field regions than VRgcFPP, (2) the comparisons of average differences in intact versus damaged amplitudes between patients and controls demonstrate high diagnostic performance of both gcFPP and VRgcFPP, and (3) the test–retest reliabilities confirm that both gcFPP and VRgcFPP reliably and consistently measure defects in homonymous hemianopia.
Key messages
What is known
Standard automated perimetry is the current gold standard for visual field examination, but not always suited for the evaluation of the VF in neurologically impaired patients.
Pupil perimetry consists of the measurement of pupillary responses to light stimuli as a measure of visual sensitivity.
What is new
This study reports the highest diagnostic accuracy of pupil perimetry so far in patients with homonymous hemianopia.
Gaze-contingent flicker pupil perimetry reliably and consistently measures defects in homonymous hemianopia under standard and virtual reality viewing conditions.
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