通过选择性分区进行转录调控：基础牢固的弱相互作用

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2024-09-19 DOI:10.1016/j.molcel.2024.08.029

Megan Palacio, Dylan J. Taatjes

引用次数: 0

摘要

在本期《分子细胞》（Molecular Cell）杂志上，De La Cruz、Pradhan、Veettil 等人1 研究了蛋白质通过低亲和性 IDR 依赖性相互作用进行选择性分区如何有助于调节 RNA 聚合酶 II（RNA Pol II）的功能，并确定了细胞中驱动分区的序列特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Transcription regulation through selective partitioning: Weak interactions with a strong foundation

In this issue of Molecular Cell, De La Cruz, Pradhan, Veettil et al.¹ examine how selective partitioning of proteins via low-affinity IDR-dependent interactions may help regulate RNA polymerase II (RNA Pol II) function and identify sequence features that drive partitioning in cells.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.