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IF 4.8 2区医学 Q1 CHEMISTRY, MEDICINAL

Journal of ethnopharmacology Pub Date : 2024-09-17 DOI:10.1016/j.jep.2024.118808

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引用次数: 0

摘要

民族药学意义2型糖尿病（T2DM）中枢神经病变引起的认知障碍，即糖尿病相关认知功能减退（DACD），是T2DM患者常见的并发症之一。研究表明，脑β-淀粉样蛋白（Aβ）沉积是 DACD 患者的典型病理变化，而肠道微生物与认知障碍之间存在密切关系。研究目的揭示 ZBPYR 调节 Aβ 代谢的机制，为 DACD 的临床评估和诊断提供理论依据。材料和方法我们对患有 DACD 的 Zucker 糖尿病肥胖大鼠（ZDF）的中枢和外周组织的 Aβ 代谢进行了表征，然后探讨了紫草皮茵陈口服液（ZBPYR）的预防和治疗作用。具体而言，我们评估了这些动物 Aβ 的形成、转运和清除；血脑屏障（BBB）的形态结构；以及 Aβ 代谢与肠道微生物之间的潜在相关性。结果ZBPYR 通过改善 ZDF 大鼠 Aβ 生成、转运和清除相关蛋白的表达，改善了 BBB 的结构，减轻了 Aβ 在中枢和外周组织中的沉积，并延缓了 DACD 的发展。此外，ZBPYR 还改善了肠道微生物的多样性和组成，降低了与 Aβ 生成密切相关的铜球菌的丰度，并提高了与 Aβ 清除密切相关的链球菌的丰度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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ZiBu PiYin recipe regulates central and peripheral Aβ metabolism and improves diabetes-associated cognitive decline in ZDF rats

Ethnopharmacological relevance

Cognitive impairment caused by central neuropathy in type 2 diabetes mellitus (T2DM), namely diabetes-associated cognitive decline (DACD), is one of the common complications in patients with T2DM. Studies have shown that brain β-amyloid (Aβ) deposition is a typical pathological change in patients with DACD, and that there is a close relationship between intestinal microorganisms and cognitive impairment. However, the specific mechanism(s) of alteration in Aβ metabolism in DACD, and of the correlation between Aβ metabolism and intestinal microorganisms remain unknown.

Aim of the study

Revealing the mechanism of ZBPYR regulating Aβ metabolism and providing theoretical basis for clinical evaluation and diagnosis of DACD.

Materials and methods

We characterized Aβ metabolism in the central and peripheral tissues of Zucker diabetic fatty (ZDF) rats with DACD, and then explored the preventive and therapeutic effects of ZiBu PiYin Recipe (ZBPYR). Specifically, we assessed these animals for the formation, transport, and clearance of Aβ; the morphological structure of the blood-brain barrier (BBB); and the potential correlation between Aβ metabolism and intestinal microorganisms.

Results

ZBPYR provided improvements in the structure of the BBB, attenuation of Aβ deposition in the central and peripheral tissues, and a delay in the development of DACD by improving the expression of Aβ production, transport, and clearance related protein in ZDF rats. In addition, ZBPYR improved the diversity and composition of intestinal microorganisms, decreased the abundance of Coprococcus, a bacterium closely related to Aβ production, and up regulate the abundance of Streptococcus, a bacterium closely related to Aβ clearance.

Conclusion

The mechanism of ZBPYR ability to ameliorate DACD may be closely related to changes in the intestinal microbiome.

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来源期刊

Journal of ethnopharmacology 医学-全科医学与补充医学

CiteScore

10.30

自引率

5.60%

发文量

967

审稿时长

77 days

期刊介绍： The Journal of Ethnopharmacology is dedicated to the exchange of information and understandings about people''s use of plants, fungi, animals, microorganisms and minerals and their biological and pharmacological effects based on the principles established through international conventions. Early people confronted with illness and disease, discovered a wealth of useful therapeutic agents in the plant and animal kingdoms. The empirical knowledge of these medicinal substances and their toxic potential was passed on by oral tradition and sometimes recorded in herbals and other texts on materia medica. Many valuable drugs of today (e.g., atropine, ephedrine, tubocurarine, digoxin, reserpine) came into use through the study of indigenous remedies. Chemists continue to use plant-derived drugs (e.g., morphine, taxol, physostigmine, quinidine, emetine) as prototypes in their attempts to develop more effective and less toxic medicinals.