癌症中的新陈代谢改变:洞察能量途径和治疗目标

IF 27.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Muhammad Tufail, Can-Hua Jiang, Ning Li
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引用次数: 0

摘要

癌细胞需要进行重大的代谢重编程,以支持其快速生长和存活。本研究探讨了糖酵解、氧化磷酸化、谷氨酰胺酵解和脂质代谢等重要的代谢途径,重点是它们是如何被调控的,以及它们对肿瘤发展的贡献。我们研究了癌基因、肿瘤抑制因子、表观遗传修饰和肿瘤微环境在调节这些通路中的相互作用。此外,我们还讨论了针对癌症代谢的治疗潜力,介绍了糖酵解、谷氨酰胺酵解、TCA 循环、脂肪酸氧化、LDH 和葡萄糖转运的抑制剂,以及针对氧化磷酸化和脂质合成的新兴策略。尽管前景光明,但新陈代谢的可塑性、对综合疗法和可靠生物标志物的需求等挑战依然存在,这凸显了在这一充满活力的领域继续开展研究的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Altered metabolism in cancer: insights into energy pathways and therapeutic targets
Cancer cells undergo significant metabolic reprogramming to support their rapid growth and survival. This study examines important metabolic pathways like glycolysis, oxidative phosphorylation, glutaminolysis, and lipid metabolism, focusing on how they are regulated and their contributions to the development of tumors. The interplay between oncogenes, tumor suppressors, epigenetic modifications, and the tumor microenvironment in modulating these pathways is examined. Furthermore, we discuss the therapeutic potential of targeting cancer metabolism, presenting inhibitors of glycolysis, glutaminolysis, the TCA cycle, fatty acid oxidation, LDH, and glucose transport, alongside emerging strategies targeting oxidative phosphorylation and lipid synthesis. Despite the promise, challenges such as metabolic plasticity and the need for combination therapies and robust biomarkers persist, underscoring the necessity for continued research in this dynamic field.
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来源期刊
Molecular Cancer
Molecular Cancer 医学-生化与分子生物学
CiteScore
54.90
自引率
2.70%
发文量
224
审稿时长
2 months
期刊介绍: Molecular Cancer is a platform that encourages the exchange of ideas and discoveries in the field of cancer research, particularly focusing on the molecular aspects. Our goal is to facilitate discussions and provide insights into various areas of cancer and related biomedical science. We welcome articles from basic, translational, and clinical research that contribute to the advancement of understanding, prevention, diagnosis, and treatment of cancer. The scope of topics covered in Molecular Cancer is diverse and inclusive. These include, but are not limited to, cell and tumor biology, angiogenesis, utilizing animal models, understanding metastasis, exploring cancer antigens and the immune response, investigating cellular signaling and molecular biology, examining epidemiology, genetic and molecular profiling of cancer, identifying molecular targets, studying cancer stem cells, exploring DNA damage and repair mechanisms, analyzing cell cycle regulation, investigating apoptosis, exploring molecular virology, and evaluating vaccine and antibody-based cancer therapies. Molecular Cancer serves as an important platform for sharing exciting discoveries in cancer-related research. It offers an unparalleled opportunity to communicate information to both specialists and the general public. The online presence of Molecular Cancer enables immediate publication of accepted articles and facilitates the presentation of large datasets and supplementary information. This ensures that new research is efficiently and rapidly disseminated to the scientific community.
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