切伦科夫成像与闪烁剂量测定相结合,为植入心脏电子装置的放疗患者提供实时位置和剂量监测

IF 3.4 Q2 ONCOLOGY
Savannah M. Decker , Allison L. Matous , Rongxiao Zhang , David J. Gladstone , Evan K. Grove , Benjamin B. Williams , Michael Jermyn , Shauna McVorran , Lesley A. Jarvis
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引用次数: 0

摘要

背景和目的心脏植入电子装置(CIED)需要在每次放疗期间进行剂量监测,这可能会耗费大量时间,而且可能会延迟读出时间。本研究探讨了切伦科夫成像与闪烁剂量测定相结合作为替代验证系统的潜力。方法和材料使用时间门控互补金属氧化物半导体(iCMOS)相机收集拟人化模型和正在胸壁心脏设备附近接受放射治疗的患者的视频图像。闪烁盘和光学激发发光剂量计(OSLD)用于剂量测量。通过将治疗计划系统(TPS)得出的预测表面剂量轮廓与切伦科夫图像进行叠加,评估了空间给药的准确性。结果在模型研究中,与非重叠剂量投放相比,切伦科夫图像能明显显示何时将剂量投放到 CIED。与剂量叠加进行比较后发现,在计划位置上的剂量是一致的,而当模型从初始位置移动时则不一致。在三个不同的位置,闪烁盘得出的绝对剂量与 OSLD 测量值和 TPS 预测值十分吻合,场内位置的测量值在 10% 以内,场外位置的测量值在 5% 以内。结论切伦科夫成像与闪烁剂量测定相结合,为CIED监测提供了另一种方法,其优点是能即时发现偏差,从而及时采取纠正措施或对患者进行适当分流。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cherenkov imaging combined with scintillation dosimetry provides real-time positional and dose monitoring for radiotherapy patients with cardiac implanted electronic devices

Background and purpose

Cardiac implanted electronic devices (CIED) require dose monitoring during each fraction of radiotherapy, which can be time consuming and may have delayed read-out times. This study explores the potential of Cherenkov imaging combined with scintillation dosimetry as an alternative verification system.

Methods and materials

Time-gated, complementary metal–oxide–semiconductor (iCMOS) cameras were used to collect video images of anthropomorphic phantoms and patients undergoing radiation treatment near chest wall cardiac devices. Scintillator discs and optically stimulated luminescence dosimeters (OSLDs) were used for dose measurement. Accuracy of spatial delivery was assessed by overlaying predicted surface dose outlines derived from the treatment planning system (TPS) with the Cherenkov images. Dose measurements from OSLDs and scintillators were compared.

Results

In phantom studies, Cherenkov images visibly indicated when dose was delivered to the CIED as compared to non-overlapping dose deliveries. Comparison with dose overlays revealed congruence at the planned position and non-congruence when the phantom was shifted from the initial position. Absolute doses derived from scintillator discs aligned well with the OSLD measurements and TPS predictions for three different positions, measuring within 10 % for in-field positions and within 5 % for out-of-field positions. For two patients with CIEDs imaged over 18 fractions, Cherenkov imaging confirmed positional accuracy for all fractions, and dose measured by scintillator discs deviated by <0.015 Gy from the OSLD measurements.

Conclusions

Cherenkov imaging combined with scintillation dosimetry presents an alternative methodology for CIED monitoring with the added benefit of instantly detecting deviations, enabling timely corrective actions or proper patient triage.

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来源期刊
Physics and Imaging in Radiation Oncology
Physics and Imaging in Radiation Oncology Physics and Astronomy-Radiation
CiteScore
5.30
自引率
18.90%
发文量
93
审稿时长
6 weeks
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