{"title":"新型二维镍基复合物通过增强活性氧的生成调节 SKOV3 细胞凋亡","authors":"","doi":"10.1016/j.molstruc.2024.140005","DOIUrl":null,"url":null,"abstract":"<div><p>Disrupting cancer cells' fragile redox balance is one of the most promising cancer therapy strategies. Ovarian malignant tumours, the most common gynecological malignant tumours, are difficult to treat. Therefore, the search for highly effective and low-toxicity drugs for ovarian cancer treatment has become an urgent challenge for scientists to break through. Based on the excellent bio-activity and anti-tumour properties of metal-organic complexes, a novel nickel-based complex with a 2D structure was synthesized in this paper. Based on the experimental results, it was found that the <strong>Ni complex</strong> up-regulated the intracellular oxidation level of ovarian cancer cells SKOV3 to generate more reactive oxygen species (ROS). This enhanced mitochondrial breakage and DNA damage, and ultimately led to ovarian tumour cell apoptosis.</p></div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":null,"pages":null},"PeriodicalIF":4.0000,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A novel two-dimensional nickel-based complex regulate apoptosis in SKOV3 cells by enhancing reactive oxygen species generation\",\"authors\":\"\",\"doi\":\"10.1016/j.molstruc.2024.140005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Disrupting cancer cells' fragile redox balance is one of the most promising cancer therapy strategies. Ovarian malignant tumours, the most common gynecological malignant tumours, are difficult to treat. Therefore, the search for highly effective and low-toxicity drugs for ovarian cancer treatment has become an urgent challenge for scientists to break through. Based on the excellent bio-activity and anti-tumour properties of metal-organic complexes, a novel nickel-based complex with a 2D structure was synthesized in this paper. Based on the experimental results, it was found that the <strong>Ni complex</strong> up-regulated the intracellular oxidation level of ovarian cancer cells SKOV3 to generate more reactive oxygen species (ROS). This enhanced mitochondrial breakage and DNA damage, and ultimately led to ovarian tumour cell apoptosis.</p></div>\",\"PeriodicalId\":16414,\"journal\":{\"name\":\"Journal of Molecular Structure\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2024-09-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Molecular Structure\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0022286024025146\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Molecular Structure","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022286024025146","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
摘要
破坏癌细胞脆弱的氧化还原平衡是最有前途的癌症治疗策略之一。卵巢恶性肿瘤是最常见的妇科恶性肿瘤,治疗难度大。因此,寻找高效低毒的卵巢癌治疗药物已成为科学家亟待突破的难题。基于金属有机配合物优异的生物活性和抗肿瘤特性,本文合成了一种二维结构的新型镍基配合物。实验结果发现,镍络合物能提高卵巢癌细胞 SKOV3 的细胞内氧化水平,产生更多的活性氧(ROS)。这增强了线粒体断裂和 DNA 损伤,最终导致卵巢肿瘤细胞凋亡。
A novel two-dimensional nickel-based complex regulate apoptosis in SKOV3 cells by enhancing reactive oxygen species generation
Disrupting cancer cells' fragile redox balance is one of the most promising cancer therapy strategies. Ovarian malignant tumours, the most common gynecological malignant tumours, are difficult to treat. Therefore, the search for highly effective and low-toxicity drugs for ovarian cancer treatment has become an urgent challenge for scientists to break through. Based on the excellent bio-activity and anti-tumour properties of metal-organic complexes, a novel nickel-based complex with a 2D structure was synthesized in this paper. Based on the experimental results, it was found that the Ni complex up-regulated the intracellular oxidation level of ovarian cancer cells SKOV3 to generate more reactive oxygen species (ROS). This enhanced mitochondrial breakage and DNA damage, and ultimately led to ovarian tumour cell apoptosis.
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