1-oxa-9-azaspiro[5.5]undecane 衍生物的合成及其抗结核活性的优化

IF 1.4 4区化学 Q3 CHEMISTRY, ORGANIC

Chemistry of Heterocyclic Compounds Pub Date : 2024-08-21 DOI:10.1007/s10593-024-03328-w

Kristina Yu. Komarova, Alexey Yu. Lukin, Lyubov V. Vinogradova, Maxim E. Zhuravlev, Marine Z. Dogonadze, Tatiana I. Vinogradova, Maxim A. Gureev, Mikhail V. Chudinov, Dmitry V. Dar’in

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引用次数: 0

摘要

这项工作的目的是合成和研究含有 1-oxa-9-azaspiro[5.5]undecane 支架的结核杆菌 MmpL3 蛋白的螺环抑制剂的抗结核活性。考虑到分子对接的结果，对初始结构进行了优化。由此产生的化合物以外围片段的化学多样性为特征，对抗生素敏感菌株 H37Rv 和一些结核杆菌多重耐药菌株表现出较高的活性，超过了对比药物的活性。

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The synthesis of 1-oxa-9-azaspiro[5.5]undecane derivatives and optimization of antituberculosis activity thereof

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The synthesis of 1-oxa-9-azaspiro[5.5]undecane derivatives and optimization of antituberculosis activity thereof

The aim of this work was to synthesize and study the antituberculosis activity of spirocyclic inhibitors of the MmpL3 protein of M. tu- berculosis containing the 1-oxa-9-azaspiro[5.5]undecane scaffold. Optimization of the initial structure was performed with consideration of the results of molecular docking. The resulting compounds, characterized by the chemical diversity of the peripheral fragment, showed high activity against the antibiotic-sensitive strain H37Rv and some multiresistant strains of M. tuberculosis, exceeding the activity of the comparator drug.

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来源期刊

Chemistry of Heterocyclic Compounds 化学-有机化学

CiteScore

2.90

自引率

13.30%

发文量

审稿时长

1 months

期刊介绍： The international journal Chemistry of Heterocyclic Compounds publishes original papers, short communications, reviews, and mini-reviews dealing with problems in the field of heterocyclic chemistry in Russian and English. The Journal also publishes reviews and annotations on new books and brief reports on conferences in the field of heterocyclic chemistry, as well as commemoratives dedicated to prominent heterocyclic chemists.