微生物群与急性器官损伤：聚焦肾脏

IF 4.8 2区医学 Q1 TRANSPLANTATION

Nephrology Dialysis Transplantation Pub Date : 2024-09-07 DOI:10.1093/ndt/gfae196

Shishir Kumar Patel, Mahta Gooya, Qisen Guo, Sanjeev Noel, Hamid Rabb

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引用次数: 0

摘要

在重症监护期间，重症患者的微生物组会因疾病和临床干预措施的影响而发生重大改变。研究表明，在实验模型和初步临床试验中，操纵微生物组可以预防或调节危重症并发症。本综述旨在讨论微生物组的一般概念，包括改变急性器官功能障碍的机制。重点将放在实验性急性肾损伤（不包括脓毒性 AKI）期间微生物组调节的效果，以及与危重病人常见的其他实验性急性器官损伤的比较。

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The microbiome and acute organ injury: focus on kidneys

The microbiome of critically ill patients is significantly altered by both effects of the illnesses and clinical interventions provided during intensive care. Studies have shown that manipulating the microbiome can prevent or modulate complications of critical illness in experimental models and preliminary clinical trials. This review aims to discuss general concepts about the microbiome, including mechanisms of modifying acute organ dysfunction. The focus will be on the effects of microbiome modulation during experimental acute kidney injury (excluding septic AKI) and comparison with other experimental acute organ injuries commonly seen in critically ill patients.

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来源期刊

Nephrology Dialysis Transplantation 医学-泌尿学与肾脏学

CiteScore

10.10

自引率

4.90%

发文量

1431

审稿时长

1.7 months

期刊介绍： Nephrology Dialysis Transplantation (ndt) is the leading nephrology journal in Europe and renowned worldwide, devoted to original clinical and laboratory research in nephrology, dialysis and transplantation. ndt is an official journal of the [ERA-EDTA](http://www.era-edta.org/) (European Renal Association-European Dialysis and Transplant Association). Published monthly, the journal provides an essential resource for researchers and clinicians throughout the world. All research articles in this journal have undergone peer review. Print ISSN: 0931-0509.