Jong Bhak, Dougu Nam, Kyungwhan An, Yoonsung Kwon, Jihun Bhak, Sungwon Jeon, Hyojung Ryu
{"title":"全血生理压力造成的可逆转录组年龄变化","authors":"Jong Bhak, Dougu Nam, Kyungwhan An, Yoonsung Kwon, Jihun Bhak, Sungwon Jeon, Hyojung Ryu","doi":"10.1101/2024.09.08.611853","DOIUrl":null,"url":null,"abstract":"We develop a genome-wide transcriptomic clock for predicting chronological age using whole blood samples from 463 healthy individuals. Our findings reveal profound age acceleration, up to 24.47 years, under perturbed homeostasis in COVID-19 patients, which reverted to baseline upon recovery. This study demonstrates that the whole blood transcriptome can track reversible changes in biological age induced by stressors in real physiological time, suggesting a potential role for anti-aging interventions in disease management.","PeriodicalId":501307,"journal":{"name":"bioRxiv - Bioinformatics","volume":"62 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Reversible Transcriptomic Age Shifts from Physiological Stress in Whole Blood\",\"authors\":\"Jong Bhak, Dougu Nam, Kyungwhan An, Yoonsung Kwon, Jihun Bhak, Sungwon Jeon, Hyojung Ryu\",\"doi\":\"10.1101/2024.09.08.611853\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We develop a genome-wide transcriptomic clock for predicting chronological age using whole blood samples from 463 healthy individuals. Our findings reveal profound age acceleration, up to 24.47 years, under perturbed homeostasis in COVID-19 patients, which reverted to baseline upon recovery. This study demonstrates that the whole blood transcriptome can track reversible changes in biological age induced by stressors in real physiological time, suggesting a potential role for anti-aging interventions in disease management.\",\"PeriodicalId\":501307,\"journal\":{\"name\":\"bioRxiv - Bioinformatics\",\"volume\":\"62 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"bioRxiv - Bioinformatics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.09.08.611853\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"bioRxiv - Bioinformatics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.08.611853","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Reversible Transcriptomic Age Shifts from Physiological Stress in Whole Blood
We develop a genome-wide transcriptomic clock for predicting chronological age using whole blood samples from 463 healthy individuals. Our findings reveal profound age acceleration, up to 24.47 years, under perturbed homeostasis in COVID-19 patients, which reverted to baseline upon recovery. This study demonstrates that the whole blood transcriptome can track reversible changes in biological age induced by stressors in real physiological time, suggesting a potential role for anti-aging interventions in disease management.
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