IgA 肾病患者不良妊娠结局的风险因素及其对临床效果的影响：回顾性观察研究

IF 2.4 4区医学 Q2 UROLOGY & NEPHROLOGY

Nephrology Pub Date : 2024-09-10 DOI:10.1111/nep.14387

Fengxia Zhang, Zhiyong Xie, Siqi Peng, Nan Jiang, Bohou Li, Boxi Chen, Shuting Deng, Ye Yuan, Qiong Wu, Sichun Wen, Yiming Tao, Jianchao Ma, Sijia Li, Ting Lin, Feng Wen, Zhuo Li, Renwei Huang, Zhonglin Feng, Chaosheng He, Wenjian Wang, Xinling Liang, Lixia Xu, Yue Shen, Niechao Hong, Ruiquan Xu, Shuangxin Liu

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Renal function outcome and proteinuria remission were evaluated in pregnant IgAN women with and without APO.ResultsIn this retrospective and observational study, we found that patients with APO exhibited higher levels of serum creatinine and IgM, and lower haemoglobin levels while other clinical characteristics, pathological characteristics and therapy protocol had no significant difference. We found that anaemia and a higher level of serum IgM were independent risk factors for APO. 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引用次数: 0

摘要

目的IgA肾病（IgAN）是全球最常见的原发性肾小球疾病。妊娠期 IgAN 患者更容易出现不良妊娠结局（APO）。方法我们进行了一项2003-2019年的回顾性观察研究，纳入了44例有妊娠史的女性IgAN患者，研究APO的风险因素及其对IgAN临床结局的影响。结果在这项回顾性观察研究中，我们发现 APO 患者的血清肌酐和 IgM 水平较高，血红蛋白水平较低，而其他临床特征、病理特征和治疗方案无显著差异。我们发现，贫血和较高的血清 IgM 水平是 APO 的独立风险因素。无 APO 的 IgAN 孕妇蛋白尿缓解的比例高于有 APO 的孕妇，但肾功能结果没有差异。

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The risk factor for adverse pregnancy outcomes and its impact on clinical effect in IgA nephropathy: A retrospective observational study

AimIgA nephropathy (IgAN) is the most common primary glomerular disease worldwide. Pregnant IgAN patients are more susceptible to adverse pregnancy outcomes (APO). However, the risk factor for APO and its effects on the long‐term renal outcome of pregnant IgAN patients remained unclear.MethodsWe performed a retrospective observational study covering 2003–2019 that included 44 female IgAN patients with pregnancy history to investigate the risk factor for APO and its impact on clinical outcome in IgAN. Renal function outcome and proteinuria remission were evaluated in pregnant IgAN women with and without APO.ResultsIn this retrospective and observational study, we found that patients with APO exhibited higher levels of serum creatinine and IgM, and lower haemoglobin levels while other clinical characteristics, pathological characteristics and therapy protocol had no significant difference. We found that anaemia and a higher level of serum IgM were independent risk factors for APO. IgAN pregnant women without APO experienced a higher proportion of proteinuria remission than those with APO, but there is no difference in the renal function outcome.ConclusionPregnant IgAN patients with higher risks, including lower haemoglobin levels and higher IgM levels deserve intensive monitoring, and aggressive therapy to reduce proteinuria should be carried out in pregnant IgAN patients with APO.

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来源期刊

Nephrology 医学-泌尿学与肾脏学

CiteScore

4.50

自引率

4.00%

发文量

128

审稿时长

4-8 weeks

期刊介绍： Nephrology is published eight times per year by the Asian Pacific Society of Nephrology. It has a special emphasis on the needs of Clinical Nephrologists and those in developing countries. The journal publishes reviews and papers of international interest describing original research concerned with clinical and experimental aspects of nephrology.