S. M. Potdar, S. S. Gurav, S. V. Raskar, K. T. Waghmode
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Hantzsch Synthesis of the Calcium Channel Blockers Nifedipine, Diludine, and Nitrendipine Using Methanesulfonic Acid as Catalyst
A simple and efficient one-pot three-component method has been developed and applied for the preparation of the calcium channel blockers nifedipine, diludine, and nitrendipine via Hantzsch dihydropyridine synthesis in good yields employing methanesulfonic acid as catalyst. The protocol stands out for mild reaction conditions, shorter reaction time, high yield, and easy workup and purification procedures, which enhance its practicality. Furthermore, the use of inexpensive and greener catalyst contributes to the efficacy and feasibility of the presented synthetic approach.
期刊介绍:
Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.