钌催化的 2-(Het)芳基[1,2,4]三唑并[1,5-a]嘧啶与芳基卤化物的区域选择性 C7-H 芳基化反应

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2024-08-30 DOI:10.1134/s1070428024060095

K. E. Shepelenko, I. G. Gnatiuk, V. M. Chernyshev

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引用次数: 0

摘要

摘要在钌(II)配合物的催化下，2-(het)芳基[1,2,4]三唑并[1,5-a]嘧啶与(het)芳基卤化物的 C-H 芳基化方向被揭示出来。该反应涉及活化三唑并嘧啶核心 C2 处(het)芳基取代基的 C7-H 键而不是 Cα-H 键。将 2-取代的 [1,2,4]三唑并[1,5-a]嘧啶与 (庚)芳基溴化物进行芳基化反应，得到了一系列 7-(庚)芳基衍生物，产率良好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ruthenium-Catalyzed Regioselective C7–H Arylation of 2-(Het)aryl[1,2,4]triazolo[1,5-a]pyrimidines with Aryl Halides

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Ruthenium-Catalyzed Regioselective C7–H Arylation of 2-(Het)aryl[1,2,4]triazolo[1,5-a]pyrimidines with Aryl Halides

Abstract

Unusual direction of the C–H arylation of 2-(het)aryl[1,2,4]triazolo[1,5-a]pyrimidines with (het)aryl halides under catalysis by ruthenium(II) complexes has been revealed. The reaction involved activation of the C⁷–H bond rather than the C^α–H bond of the (het)aryl substituent at C² of the triazolopyrimidine core. The arylation of 2-substituted [1,2,4]triazolo[1,5-a]pyrimidines with (het)aryl bromides afforded a series of 7-(het)aryl derivatives in good yields.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.