{"title":"[18F]FDG正电子发射计算机断层显像/计算机断层扫描、核磁共振成像和计算机断层扫描在诊断口腔癌/咽癌下颌骨侵犯中的诊断效果：头对头比较荟萃分析","authors":"Siqi Zhao, Xiao Li","doi":"10.1007/s40336-024-00657-w","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>This research synthesis investigates the diagnostic performance of [<sup>18</sup>F]FDG PET/CT, MRI, and CT in detecting mandibular invasion in patients with oral and oropharyngeal cancer.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>An extensive literature review was conducted using PubMed and Embase, targeting studies up to March 2024 that examined the diagnostic capabilities of [<sup>18</sup>F]FDG PET/CT, MRI, and CT for oral and oropharyngeal cancer patients. Sensitivity and specificity were calculated using the DerSimonian and Laird random-effects model with adjustments via the Freeman-Tukey double arc sine transformation. Study quality was assessed with the QUADAS-2 tool.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>This meta-analysis synthesized data from 24 studies involving 1376 participants to compare the diagnostic performance of CT, MRI, and [<sup>18</sup>F]FDG PET/CT for mandibular invasion in oral and oropharyngeal cancer patients. The results showed closely matched sensitivity and specificity among the technologies: CT pooled a sensitivity of 0.80 and specificity of 0.85, while MRI exhibited a slightly better sensitivity at 0.87 but lower specificity at 0.81, with the differences not reaching statistical significance (all <i>P</i> > 0.05). [<sup>18</sup>F]FDG PET/CT also demonstrated comparable performance, achieving a sensitivity of 0.77 versus CT’s 0.72 and a specificity of 0.82 versus CT’s 0.93, alongside matching MRI’s sensitivity at 0.86 and a specificity of 0.68 versus MRI’s 0.75, with all comparisons showing no significant disparities (all <i>P</i> > 0.05).</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>The meta-analysis concludes that there was no statistically significant difference in diagnostic performance between [<sup>18</sup>F]FDG PET/CT, CT and MRI. Further research with prospective comparative trials is recommended to validate these findings in new clinical cohorts.</p>","PeriodicalId":48600,"journal":{"name":"Clinical and Translational Imaging","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The diagnosis performance of [18F]FDG PET/CT, MRI, and CT in the diagnosis of mandibular invasion in oral/oropharyngeal carcinoma: a head-to-head comparative meta-analysis\",\"authors\":\"Siqi Zhao, Xiao Li\",\"doi\":\"10.1007/s40336-024-00657-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Purpose</h3><p>This research synthesis investigates the diagnostic performance of [<sup>18</sup>F]FDG PET/CT, MRI, and CT in detecting mandibular invasion in patients with oral and oropharyngeal cancer.</p><h3 data-test=\\\"abstract-sub-heading\\\">Methods</h3><p>An extensive literature review was conducted using PubMed and Embase, targeting studies up to March 2024 that examined the diagnostic capabilities of [<sup>18</sup>F]FDG PET/CT, MRI, and CT for oral and oropharyngeal cancer patients. Sensitivity and specificity were calculated using the DerSimonian and Laird random-effects model with adjustments via the Freeman-Tukey double arc sine transformation. Study quality was assessed with the QUADAS-2 tool.</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>This meta-analysis synthesized data from 24 studies involving 1376 participants to compare the diagnostic performance of CT, MRI, and [<sup>18</sup>F]FDG PET/CT for mandibular invasion in oral and oropharyngeal cancer patients. The results showed closely matched sensitivity and specificity among the technologies: CT pooled a sensitivity of 0.80 and specificity of 0.85, while MRI exhibited a slightly better sensitivity at 0.87 but lower specificity at 0.81, with the differences not reaching statistical significance (all <i>P</i> > 0.05). [<sup>18</sup>F]FDG PET/CT also demonstrated comparable performance, achieving a sensitivity of 0.77 versus CT’s 0.72 and a specificity of 0.82 versus CT’s 0.93, alongside matching MRI’s sensitivity at 0.86 and a specificity of 0.68 versus MRI’s 0.75, with all comparisons showing no significant disparities (all <i>P</i> > 0.05).</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusions</h3><p>The meta-analysis concludes that there was no statistically significant difference in diagnostic performance between [<sup>18</sup>F]FDG PET/CT, CT and MRI. Further research with prospective comparative trials is recommended to validate these findings in new clinical cohorts.</p>\",\"PeriodicalId\":48600,\"journal\":{\"name\":\"Clinical and Translational Imaging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-08-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Translational Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s40336-024-00657-w\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Translational Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s40336-024-00657-w","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
The diagnosis performance of [18F]FDG PET/CT, MRI, and CT in the diagnosis of mandibular invasion in oral/oropharyngeal carcinoma: a head-to-head comparative meta-analysis
Purpose
This research synthesis investigates the diagnostic performance of [18F]FDG PET/CT, MRI, and CT in detecting mandibular invasion in patients with oral and oropharyngeal cancer.
Methods
An extensive literature review was conducted using PubMed and Embase, targeting studies up to March 2024 that examined the diagnostic capabilities of [18F]FDG PET/CT, MRI, and CT for oral and oropharyngeal cancer patients. Sensitivity and specificity were calculated using the DerSimonian and Laird random-effects model with adjustments via the Freeman-Tukey double arc sine transformation. Study quality was assessed with the QUADAS-2 tool.
Results
This meta-analysis synthesized data from 24 studies involving 1376 participants to compare the diagnostic performance of CT, MRI, and [18F]FDG PET/CT for mandibular invasion in oral and oropharyngeal cancer patients. The results showed closely matched sensitivity and specificity among the technologies: CT pooled a sensitivity of 0.80 and specificity of 0.85, while MRI exhibited a slightly better sensitivity at 0.87 but lower specificity at 0.81, with the differences not reaching statistical significance (all P > 0.05). [18F]FDG PET/CT also demonstrated comparable performance, achieving a sensitivity of 0.77 versus CT’s 0.72 and a specificity of 0.82 versus CT’s 0.93, alongside matching MRI’s sensitivity at 0.86 and a specificity of 0.68 versus MRI’s 0.75, with all comparisons showing no significant disparities (all P > 0.05).
Conclusions
The meta-analysis concludes that there was no statistically significant difference in diagnostic performance between [18F]FDG PET/CT, CT and MRI. Further research with prospective comparative trials is recommended to validate these findings in new clinical cohorts.
期刊介绍：
Clinical and Translational Imaging is an international journal that publishes timely, up-to-date summaries on clinical practice and translational research and clinical applications of approved and experimental radiopharmaceuticals for diagnostic and therapeutic purposes. Coverage includes such topics as advanced preclinical evidence in the fields of physics, dosimetry, radiation biology and radiopharmacy with relevance to applications in human subjects. The journal benefits a readership of nuclear medicine practitioners and allied professionals involved in molecular imaging and therapy.
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