Jiayu Zhang, Jie Xiong, Min Wang, Bin Wu, Chunyin Zhang
{"title":"68Ga-FAPI 和 18F-FDG PET/CT 对乳腺癌诊断价值的比较：系统性综述","authors":"Jiayu Zhang, Jie Xiong, Min Wang, Bin Wu, Chunyin Zhang","doi":"10.1007/s40336-024-00656-x","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Objective</h3><p>Although <sup>18</sup>F-FDG PET/CT is helpful in detecting primary breast cancer and its distant metastases, <sup>68</sup>Ga-FAPI PET/CT may perform better in detecting primary breast cancers at an earlier stage and metastatic lesions (lymph node, etc.). This study aimed to systematically review the diagnostic value of <sup>68</sup>Ga-FAPI PET/CT versus <sup>18</sup>F-FDG PET/CT in terms of diagnostic accuracy parameters (sensitivity, specificity) and quantitative parameters (SUVmax, TBR, etc.) for the diagnosis of primary and metastatic lesions of breast cancer.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This study followed the PRISMA guidelines for systematic reviews. A comprehensive search of the PubMed, EMBASE and Web of Science databases was performed to identify studies that met the eligibility criteria from 2000–01 to 2023–07. The quality of the relevant studies with the QUADAS-2 method was assessed via ReviewManager v.5 software. The literature included female breast cancer patients with the pathologic type of invasive carcinoma who had received both <sup>18</sup>F-FDG and <sup>68</sup>Ga-FAPI PET/CT.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>A total of 238 documents were retrieved, and 6 were ultimately included. The results revealed that <sup>68</sup>Ga-FAPI PET/CT had a greater SUVmax, TBR, and sensitivity than FDG did.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>In this study, we compared the value of <sup>68</sup>Ga-FAPI PET/CT and <sup>18</sup>F-FDG PET/CT in breast cancer patients. For both primary and metastatic foci of breast cancer, <sup>68</sup>Ga-FAPI PET/CT resulted in a higher lesion detection rate and tracer uptake. Second, <sup>68</sup>Ga-FAPI PET/CT can improve patient staging and provide some prognostic information, including the pathological response. In addition, <sup>68</sup>Ga-FAPI PET/CT imaging can detect additional lesions as a complementary tool.</p><h3 data-test=\"abstract-sub-heading\">Systematic review registration</h3><p>https://www.crd.york.ac.uk/PROSPERO/, identifier (CRD42023491138).</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of the diagnostic value of 68Ga-FAPI and 18F-FDG PET/CT in breast cancer: a systematic review\",\"authors\":\"Jiayu Zhang, Jie Xiong, Min Wang, Bin Wu, Chunyin Zhang\",\"doi\":\"10.1007/s40336-024-00656-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Objective</h3><p>Although <sup>18</sup>F-FDG PET/CT is helpful in detecting primary breast cancer and its distant metastases, <sup>68</sup>Ga-FAPI PET/CT may perform better in detecting primary breast cancers at an earlier stage and metastatic lesions (lymph node, etc.). This study aimed to systematically review the diagnostic value of <sup>68</sup>Ga-FAPI PET/CT versus <sup>18</sup>F-FDG PET/CT in terms of diagnostic accuracy parameters (sensitivity, specificity) and quantitative parameters (SUVmax, TBR, etc.) for the diagnosis of primary and metastatic lesions of breast cancer.</p><h3 data-test=\\\"abstract-sub-heading\\\">Methods</h3><p>This study followed the PRISMA guidelines for systematic reviews. A comprehensive search of the PubMed, EMBASE and Web of Science databases was performed to identify studies that met the eligibility criteria from 2000–01 to 2023–07. The quality of the relevant studies with the QUADAS-2 method was assessed via ReviewManager v.5 software. The literature included female breast cancer patients with the pathologic type of invasive carcinoma who had received both <sup>18</sup>F-FDG and <sup>68</sup>Ga-FAPI PET/CT.</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>A total of 238 documents were retrieved, and 6 were ultimately included. The results revealed that <sup>68</sup>Ga-FAPI PET/CT had a greater SUVmax, TBR, and sensitivity than FDG did.</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusion</h3><p>In this study, we compared the value of <sup>68</sup>Ga-FAPI PET/CT and <sup>18</sup>F-FDG PET/CT in breast cancer patients. For both primary and metastatic foci of breast cancer, <sup>68</sup>Ga-FAPI PET/CT resulted in a higher lesion detection rate and tracer uptake. Second, <sup>68</sup>Ga-FAPI PET/CT can improve patient staging and provide some prognostic information, including the pathological response. 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Comparison of the diagnostic value of 68Ga-FAPI and 18F-FDG PET/CT in breast cancer: a systematic review
Objective
Although 18F-FDG PET/CT is helpful in detecting primary breast cancer and its distant metastases, 68Ga-FAPI PET/CT may perform better in detecting primary breast cancers at an earlier stage and metastatic lesions (lymph node, etc.). This study aimed to systematically review the diagnostic value of 68Ga-FAPI PET/CT versus 18F-FDG PET/CT in terms of diagnostic accuracy parameters (sensitivity, specificity) and quantitative parameters (SUVmax, TBR, etc.) for the diagnosis of primary and metastatic lesions of breast cancer.
Methods
This study followed the PRISMA guidelines for systematic reviews. A comprehensive search of the PubMed, EMBASE and Web of Science databases was performed to identify studies that met the eligibility criteria from 2000–01 to 2023–07. The quality of the relevant studies with the QUADAS-2 method was assessed via ReviewManager v.5 software. The literature included female breast cancer patients with the pathologic type of invasive carcinoma who had received both 18F-FDG and 68Ga-FAPI PET/CT.
Results
A total of 238 documents were retrieved, and 6 were ultimately included. The results revealed that 68Ga-FAPI PET/CT had a greater SUVmax, TBR, and sensitivity than FDG did.
Conclusion
In this study, we compared the value of 68Ga-FAPI PET/CT and 18F-FDG PET/CT in breast cancer patients. For both primary and metastatic foci of breast cancer, 68Ga-FAPI PET/CT resulted in a higher lesion detection rate and tracer uptake. Second, 68Ga-FAPI PET/CT can improve patient staging and provide some prognostic information, including the pathological response. In addition, 68Ga-FAPI PET/CT imaging can detect additional lesions as a complementary tool.
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