阿尔茨海默病的循环微量元素变化:系统回顾和荟萃分析

IF 6 3区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Ying Qing, Jianheng Zheng, Meng Qin, Xiufen Liu, Zhao Dai, Xinyue Xu, Yingyi Luo, Shichun Li, Liqiang Wang, Shuyu Yang, Jun Du, Ying Lu, Yanfei Li
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引用次数: 0

摘要

血液循环(血液、血清、血浆)中的微量元素水平被认为在阿尔茨海默病(AD)的病理生理过程中起着一定的作用;然而,现有的研究结果却不尽相同。本研究对 AD 患者和对照组的微量元素(包括:铜 (Cu)、铁 (Fe)、锌 (Zn)、硒 (Se)、铅 (Pb)、镉 (Cd)、汞 (Hg)、锰 (Mn)、铝 (Al)、砷 (As) 和镁 (Mg))进行了系统回顾和荟萃分析,以评估 AD 患者血液循环中微量元素的变化。通过在PubMed、Web of Science和MEDLINE数据库中系统筛选2000年至今有关AD患者循环微量元素水平的病例对照研究,52项研究被纳入最终的荟萃分析。随机效应模型的结果显示,AD 患者血液循环中的镉含量(SMD = 0.79,95% CI:0.35,1.24)、汞含量(SMD = 0.59,95% CI:0.03,1.16)和铜含量(SMD = 0.70,95% CI:0.37,1.04)明显升高。04),而AD患者体内铁(SMD = - 0.58,95% CI:- 1.03,- 0.13)、硒(SMD = - 0.53,95% CI:- 0.85,- 0.21)和锌(SMD = - 0.99,95% CI:- 1.52,- 0.46)的水平则明显较低。本研究建立的数据库为探讨AD患者循环微量元素水平的变化提供了可靠的人群研究证据。监测和稳定老年人循环微量元素水平可能是AD的潜在预防目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Circulatory trace element variations in Alzheimer’s disease: a systematic review and meta-analysis

Circulatory trace element variations in Alzheimer’s disease: a systematic review and meta-analysis

Trace element levels in the circulation (blood, serum, plasma) are believed to play a role in the pathophysiologic processes of Alzheimer’s disease (AD); however, there is heterogeneity in the available findings. This study conducted a systematic review and meta-analysis of trace elements (including: copper (Cu), iron (Fe), zinc (Zn), selenium (Se), lead (Pb), cadmium (Cd), mercury (Hg), manganese (Mn), aluminum (Al), arsenic (As), and magnesium (Mg)) in AD patients and controls to assess the variation of trace elements in the circulation of AD patients. By systematically screening case–control studies on circulatory trace element levels in AD patients from 2000 to the present in the PubMed, Web of Science, and MEDLINE databases, 52 studies were included in the final meta-analysis. The results of the random-effects model showed significantly elevated circulatory levels of Cd (SMD = 0.79, 95% CI: 0.35, 1.24), Hg (SMD = 0.59, 95% CI: 0.03, 1.16), and Cu (SMD = 0.70, 95% CI: 0.37, 1.04) in AD patients, while levels of Fe (SMD = − 0.58, 95% CI: − 1.03, − 0.13), Se (SMD = − 0.53, 95% CI: − 0.85, − 0.21), and Zn (SMD = − 0.99, 95% CI: − 1.52, − 0.46) were significantly lower. The database formed in this study provides reliable population-based research evidence for exploring changes in circulating trace element levels in AD patients. Monitoring and stabilization of circulatory trace element levels in the elderly may be a potential preventive target for AD.

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来源期刊
Environmental Sciences Europe
Environmental Sciences Europe Environmental Science-Pollution
CiteScore
11.20
自引率
1.70%
发文量
110
审稿时长
13 weeks
期刊介绍: ESEU is an international journal, focusing primarily on Europe, with a broad scope covering all aspects of environmental sciences, including the main topic regulation. ESEU will discuss the entanglement between environmental sciences and regulation because, in recent years, there have been misunderstandings and even disagreement between stakeholders in these two areas. ESEU will help to improve the comprehension of issues between environmental sciences and regulation. ESEU will be an outlet from the German-speaking (DACH) countries to Europe and an inlet from Europe to the DACH countries regarding environmental sciences and regulation. Moreover, ESEU will facilitate the exchange of ideas and interaction between Europe and the DACH countries regarding environmental regulatory issues. Although Europe is at the center of ESEU, the journal will not exclude the rest of the world, because regulatory issues pertaining to environmental sciences can be fully seen only from a global perspective.
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