Tetiana Motsak, Barend M. Mol, Joost K.R. Hoekstra, Valentina Osorio Zuluaga, Saskia Rumpff-Derksen, Ioanna Paspali-Strik, Sofon Cam Ngan, Gerard Pasterkamp, Gert J. de Borst, Siu Kwan Sze, Dominique P.V. de Kleijn
{"title":"在接受颈动脉内膜切除术的患者中,高水平的 IsoDGR 修饰纤连蛋白与较高水平的巨噬细胞和其他易破裂斑块特征有关","authors":"Tetiana Motsak, Barend M. Mol, Joost K.R. Hoekstra, Valentina Osorio Zuluaga, Saskia Rumpff-Derksen, Ioanna Paspali-Strik, Sofon Cam Ngan, Gerard Pasterkamp, Gert J. de Borst, Siu Kwan Sze, Dominique P.V. de Kleijn","doi":"10.1101/2024.09.02.24312942","DOIUrl":null,"url":null,"abstract":"<strong>Objective</strong> Deamidation of the NGR (Asn-Gly-Arg) motif to the isoDGR (isoAsp-Gly-Arg) motif in fibronectin (IsoDGR-fibronectin) enhances <em>in vitro</em> monocyte and endothelial cell activation. Blocking isoDGR reduces macrophage influx in murine tissues. Although macrophage influx is an important feature of human plaque destabilization, the role for plasma and plaque isoDGR-fibronectin in macrophage influx in the atherosclerotic plaque and thereby increasing plaque vulnerability has not been investigated in large human cohorts.","PeriodicalId":501297,"journal":{"name":"medRxiv - Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"High levels of IsoDGR-modified fibronectin are associated with higher levels of macrophages and other rupture-prone plaque characteristics in patients undergoing carotid endarterectomy\",\"authors\":\"Tetiana Motsak, Barend M. Mol, Joost K.R. Hoekstra, Valentina Osorio Zuluaga, Saskia Rumpff-Derksen, Ioanna Paspali-Strik, Sofon Cam Ngan, Gerard Pasterkamp, Gert J. de Borst, Siu Kwan Sze, Dominique P.V. de Kleijn\",\"doi\":\"10.1101/2024.09.02.24312942\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<strong>Objective</strong> Deamidation of the NGR (Asn-Gly-Arg) motif to the isoDGR (isoAsp-Gly-Arg) motif in fibronectin (IsoDGR-fibronectin) enhances <em>in vitro</em> monocyte and endothelial cell activation. Blocking isoDGR reduces macrophage influx in murine tissues. Although macrophage influx is an important feature of human plaque destabilization, the role for plasma and plaque isoDGR-fibronectin in macrophage influx in the atherosclerotic plaque and thereby increasing plaque vulnerability has not been investigated in large human cohorts.\",\"PeriodicalId\":501297,\"journal\":{\"name\":\"medRxiv - Cardiovascular Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medRxiv - Cardiovascular Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.09.02.24312942\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Cardiovascular Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.02.24312942","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
High levels of IsoDGR-modified fibronectin are associated with higher levels of macrophages and other rupture-prone plaque characteristics in patients undergoing carotid endarterectomy
Objective Deamidation of the NGR (Asn-Gly-Arg) motif to the isoDGR (isoAsp-Gly-Arg) motif in fibronectin (IsoDGR-fibronectin) enhances in vitro monocyte and endothelial cell activation. Blocking isoDGR reduces macrophage influx in murine tissues. Although macrophage influx is an important feature of human plaque destabilization, the role for plasma and plaque isoDGR-fibronectin in macrophage influx in the atherosclerotic plaque and thereby increasing plaque vulnerability has not been investigated in large human cohorts.