在接受颈动脉内膜切除术的患者中,高水平的 IsoDGR 修饰纤连蛋白与较高水平的巨噬细胞和其他易破裂斑块特征有关

Tetiana Motsak, Barend M. Mol, Joost K.R. Hoekstra, Valentina Osorio Zuluaga, Saskia Rumpff-Derksen, Ioanna Paspali-Strik, Sofon Cam Ngan, Gerard Pasterkamp, Gert J. de Borst, Siu Kwan Sze, Dominique P.V. de Kleijn
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引用次数: 0

摘要

目的 将纤维粘连蛋白(IsoDGR-fibronectin)中的 NGR(Asn-Gly-Arg)基团脱氨为 isoDGR(isoAsp-Gly-Arg)基团可增强体外单核细胞和内皮细胞的活化。阻断 isoDGR 可减少小鼠组织中巨噬细胞的涌入。虽然巨噬细胞涌入是人类斑块失稳的一个重要特征,但血浆和斑块中的异DGR-纤连蛋白在巨噬细胞涌入动脉粥样硬化斑块从而增加斑块脆弱性方面的作用尚未在大型人类队列中进行研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High levels of IsoDGR-modified fibronectin are associated with higher levels of macrophages and other rupture-prone plaque characteristics in patients undergoing carotid endarterectomy
Objective Deamidation of the NGR (Asn-Gly-Arg) motif to the isoDGR (isoAsp-Gly-Arg) motif in fibronectin (IsoDGR-fibronectin) enhances in vitro monocyte and endothelial cell activation. Blocking isoDGR reduces macrophage influx in murine tissues. Although macrophage influx is an important feature of human plaque destabilization, the role for plasma and plaque isoDGR-fibronectin in macrophage influx in the atherosclerotic plaque and thereby increasing plaque vulnerability has not been investigated in large human cohorts.
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