中风和脑血管的图像：通过先进技术对颈动脉分叉处 U 形弹性蛋白分布和无序纤维排列的新见解和详细可视化分析

IF 4.4 1区医学 Q1 CLINICAL NEUROLOGY

Stroke and Vascular Neurology Pub Date : 2024-09-11 DOI:10.1136/svn-2024-003528

Shen Li, Peipei Li, Xin Wang, Zongping Xia, Yuming Xu

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引用次数: 0

摘要

颅内动脉和颅外动脉的分叉区是动脉粥样硬化的常见部位，容易导致缺血性中风1 。先前的研究表明，分叉区独特的血液动力学可能导致该区域基因和蛋白质的改变2 。小鼠是研究动脉粥样硬化最常用的动物模型。本研究以颈动脉分叉为研究对象，优化了 iDISCO（溶剂清除器官免疫标记三维成像）技术，对颈动脉进行全组织清除和染色。

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Pictures of stroke and cerebral vasculature: novel insights and detailed visualisation of U-shaped elastin distribution and disorganised fibre arrangement at carotid bifurcations by advanced techniques

The bifurcation regions of intracranial and extracranial arteries are common sites for atherosclerosis, predisposing to ischaemic stroke.1 Previous studies have shown that the unique haemodynamics at the bifurcation may lead to alterations in genes and proteins in this region.2 Elastin is closely associated with the progression of atherosclerosis.3 However, under physiological conditions, the expression and distribution of elastin in bifurcation regions have not yet been elucidated. Mice are the most frequently used animal model for studying atherosclerosis. This study focuses on carotid bifurcation, optimising the iDISCO (immunolabeling-enabled three-dimensional imaging of solvent-cleared organs) technique for whole tissue clearing and staining of the carotid …

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来源期刊

Stroke and Vascular Neurology Medicine-Cardiology and Cardiovascular Medicine

CiteScore

11.20

自引率

1.70%

发文量

审稿时长

15 weeks

期刊介绍： Stroke and Vascular Neurology (SVN) is the official journal of the Chinese Stroke Association. Supported by a team of renowned Editors, and fully Open Access, the journal encourages debate on controversial techniques, issues on health policy and social medicine.