超声辅助细胞脊髓支架治疗脊髓损伤

IF 2.9 3区材料科学 Q2 MATERIALS SCIENCE, COATINGS & FILMS

Coatings Pub Date : 2024-09-04 DOI:10.3390/coatings14091137

Xi Deng, Yun Liu, Zhongsheng Xu, Hong Yin

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引用次数: 0

摘要

在全球范围内，脊髓损伤（SCI）治疗仍面临挑战，突破有限。组织工程学带来了希望，尤其是使用无细胞脊髓支架。本研究开发了一种 1-乙基-（3-二甲胺基丙基）盐酸碳二亚胺（EDC）交联血管内皮生长因子（VEGF）修饰的无细胞脊髓支架，用于持续释放血管内皮生长因子。结果表明，在不改变支架特性的情况下，血管内皮生长因子可持续释放 20 天。在不增加细胞毒性的情况下，还观察到稳定性和机械性能的增强。在大鼠 SCI 模型中，该系统改善了运动功能，减少了神经胶质瘢痕，恢复了脊髓形态和组织学，显示了 SCI 治疗的潜力。

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Ultrasound-Assisted Acellular Spinal Cord Scaffold for Spinal Cord Injury Treatment

Spinal cord injury (SCI) treatment remains challenging globally, with limited breakthroughs. Tissue engineering offers promise, particularly using acellular spinal cord scaffolds. This study developed a 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC)-crosslinked vascular endothelial growth factor (VEGF)-modified acellular spinal cord scaffold for sustained VEGF release. The results show sustained VEGF release over 20 days without altering the scaffold’s properties. Enhanced stability and mechanical properties were observed without increased cytotoxicity. In a rat SCI model, the system improved motor function, reduced glial scarring, and restored spinal cord morphology and histology, indicating potential for SCI therapy.

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来源期刊

Coatings Materials Science-Surfaces, Coatings and Films

CiteScore

5.00

自引率

11.80%

发文量

1657

审稿时长

1.4 months

期刊介绍： Coatings is an international, peer-reviewed open access journal of coatings and surface engineering. It publishes reviews, research articles, communications and technical notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. Full experimental and/or methodical details must be provided. There are, in addition, unique features of this journal: * manuscripts regarding research proposals and research ideas will be particularly welcomed * electronic files or software regarding the full details of the calculation and experimental procedure - if unable to be published in a normal way - can be deposited as supplementary material