{"title":"一名儿童摄入可卡因后出现通气/灌注不匹配：病例报告","authors":"Jacqueline Jones, Palen Mallory","doi":"10.1007/s42399-024-01725-y","DOIUrl":null,"url":null,"abstract":"<p>The effects of acute cocaine toxicity on lung physiology and potential ventilation/perfusion (V/Q) mismatch in children is not well described. Herein, we report a case of V/Q mismatch and profound end-tidal CO<sub>2</sub> (EtCO<sub>2</sub>) to serum partial pressure CO<sub>2</sub> (PCO<sub>2</sub>) discordance occurring in a child who tested positive for cocaine, thought to be from cocaine-induced pulmonary vasospasm (dead space). This has not previously been described in the pediatric population. Clinicians should consider the possibility of cocaine-induced pulmonary vasospasm and V/Q mismatch in children with altered mental status and otherwise unexplained significant EtCO<sub>2</sub> and PCO<sub>2</sub> discordance.</p>","PeriodicalId":21944,"journal":{"name":"SN Comprehensive Clinical Medicine","volume":"59 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ventilation/Perfusion Mismatch in a Child Following Cocaine Ingestion: Case Report\",\"authors\":\"Jacqueline Jones, Palen Mallory\",\"doi\":\"10.1007/s42399-024-01725-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The effects of acute cocaine toxicity on lung physiology and potential ventilation/perfusion (V/Q) mismatch in children is not well described. Herein, we report a case of V/Q mismatch and profound end-tidal CO<sub>2</sub> (EtCO<sub>2</sub>) to serum partial pressure CO<sub>2</sub> (PCO<sub>2</sub>) discordance occurring in a child who tested positive for cocaine, thought to be from cocaine-induced pulmonary vasospasm (dead space). This has not previously been described in the pediatric population. Clinicians should consider the possibility of cocaine-induced pulmonary vasospasm and V/Q mismatch in children with altered mental status and otherwise unexplained significant EtCO<sub>2</sub> and PCO<sub>2</sub> discordance.</p>\",\"PeriodicalId\":21944,\"journal\":{\"name\":\"SN Comprehensive Clinical Medicine\",\"volume\":\"59 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"SN Comprehensive Clinical Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s42399-024-01725-y\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"SN Comprehensive Clinical Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s42399-024-01725-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Ventilation/Perfusion Mismatch in a Child Following Cocaine Ingestion: Case Report
The effects of acute cocaine toxicity on lung physiology and potential ventilation/perfusion (V/Q) mismatch in children is not well described. Herein, we report a case of V/Q mismatch and profound end-tidal CO2 (EtCO2) to serum partial pressure CO2 (PCO2) discordance occurring in a child who tested positive for cocaine, thought to be from cocaine-induced pulmonary vasospasm (dead space). This has not previously been described in the pediatric population. Clinicians should consider the possibility of cocaine-induced pulmonary vasospasm and V/Q mismatch in children with altered mental status and otherwise unexplained significant EtCO2 and PCO2 discordance.
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