非对映选择性 C(sp3)-H-环化实现新一代环烷糖肽的设计

ChemRxiv Pub Date : 2024-09-13 DOI:10.26434/chemrxiv-2024-zgxwt

Samir, MESSAOUDI, Sokna , Bazzi, Ameni , Hadj Mohamed, Dmytro , Ryzhakov, Juba , Ghouilem, Mehdi A. , Beniddir, Vincent , Gandon

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摘要

在此，我们报告了一条通过选择性 C-H 芳基化异构键合成糖肽的大环化路线。这种方法证明了 Pd 催化 C-H 活化技术在获得陌生环肽方面的强大威力。

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Diastereoselective Anomeric C(sp3)-H Cyclization Towards the Design of New Generations of Cyclophane-Braced Glycopeptides

Here we report a macrocyclization route towards the synthesis of glycophane peptides by a selective C-H arylation of the anomeric bond. This approach demonstrates the power of Pd-catalysis C-H activation to access unfamiliar cyclic peptides

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ChemRxiv

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