生成五至九个成员环的还原 Heck 环化反应的最新进展

IF 1.7 3区 化学 Q3 CHEMISTRY, ORGANIC
Santanu Chakravorty
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引用次数: 0

摘要

:钯催化的反应被广泛用于生成碳-碳键和碳-异原子键,其中赫克反应对形成各种大小的环,包括中型环特别有价值。最近的报告显示,分子内 Heck 反应具有合成 7 个或更多成员环的潜力。虽然在没有指导基团的情况下,这种环化反应的区域选择性往往难以预测,但还原性 Heck 环化反应策略有助于最大限度地减少这一问题。镍催化剂因其丰富的资源和环保特性也很有价值,在生产具有重要生物意义的碳环和杂环方面发挥着关键作用。使用钯(0)和镍(0)催化剂,无论是否含有手性配体,都能以简单、经济的方式成功地形成五至九元环杂环和碳环。本综述全面回顾了过去十年中有关还原性 Heck 环化方法的文献,包括所需的机理细节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent Advance in the Reductive Heck Cyclization for the Formation of Five to Nine Member Rings
: Palladium-catalyzed reactions are widely used for creating carbon-carbon and carbon-heteroatom bonds, with the Heck reaction being particularly valuable for forming rings of various sizes, including mediumsized rings. Recent reports have shown the synthetic potential of intramolecular Heck reactions for assembling rings of seven or more members. While the regioselectivity of this cyclization is often unpredictable in the absence of directing groups, the reductive Heck cyclization strategy can help minimize this issue. Nickel catalysts are also valuable due to their abundance and environmentally friendly nature, playing a pivotal role in producing biologically significant carbocycles and heterocycles. The use of both Pd(0) and Ni(0) catalysts, with or without chiral ligands, has been successful in forming five to nine-member ring heterocycles and carbocycles in a simple, cost-effective manner. This review provides a comprehensive survey of the literature from the past decade on the use of reductive Heck cyclization methodology, including mechanistic details as needed.
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来源期刊
Current Organic Chemistry
Current Organic Chemistry 化学-有机化学
CiteScore
3.70
自引率
7.70%
发文量
76
审稿时长
1 months
期刊介绍: Current Organic Chemistry aims to provide in-depth/mini reviews on the current progress in various fields related to organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic and green chemistry, suitable aspects of medicinal chemistry and polymer chemistry, as well as analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers focusing on hot topics, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry, who wish to keep abreast with recent developments in key fields of organic chemistry.
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