探索虾青素作为功能性食品配料的益处:虾青素对多囊卵巢综合征妇女氧化应激和生殖结果的影响--随机临床试验的系统回顾和单臂荟萃分析

Victória Dogani Rodrigues, Beatriz Leme Boaro, Lívia Fornari Laurindo, Eduardo Federighi Baisi Chagas, Enzo Pereira de Lima, Lucas Fornari Laurindo, Sandra Maria Barbalho
{"title":"探索虾青素作为功能性食品配料的益处:虾青素对多囊卵巢综合征妇女氧化应激和生殖结果的影响--随机临床试验的系统回顾和单臂荟萃分析","authors":"Victória Dogani Rodrigues, Beatriz Leme Boaro, Lívia Fornari Laurindo, Eduardo Federighi Baisi Chagas, Enzo Pereira de Lima, Lucas Fornari Laurindo, Sandra Maria Barbalho","doi":"10.1007/s00210-024-03432-w","DOIUrl":null,"url":null,"abstract":"<p>Polycystic ovary syndrome (PCOS) is a prevalent gynecological-endocrinological disorder characterized by hyperandrogenism, menstrual irregularities, and metabolic disturbances. Recent research has highlighted the role of oxidative stress and chronic inflammation in exacerbating PCOS symptoms and impeding reproductive outcomes. Astaxanthin, a potent antioxidant found in marine organisms, has been suggested as a potential therapeutic intervention due to its ability to reduce oxidative stress and inflammation. This meta-analysis systematically reviews randomized controlled trials assessing the impact of astaxanthin supplementation on oxidative stress and reproductive outcomes in women with PCOS. Data from four trials were analyzed, focusing on markers of oxidative stress and reproductive health metrics. The meta-analysis utilized fixed and random-effects models to synthesize results, with heterogeneity assessed using Chi-square and I<sup>2</sup> statistics. The findings indicate that while astaxanthin significantly improves markers of total antioxidant capacity (TAC) in follicular fluid, it does not show a consistent effect on other oxidative stress biomarkers such as malondialdehyde (MDA), catalase (CAT), or superoxide dismutase (SOD). Reproductive outcomes, including oocyte quality and the number of high-quality embryos, showed moderate improvements, although effects on fertilization rates and pregnancy outcomes were insignificant. The analysis highlights variability in study designs and dosing, suggesting a need for further research with standardized protocols and larger sample sizes. Future studies should focus on determining optimal dosing, exploring mechanistic pathways, and investigating the combined effects of astaxanthin with other interventions. Longitudinal studies are needed to assess long-term benefits and safety, and personalized approaches could enhance treatment efficacy for individuals with PCOS.</p>","PeriodicalId":18862,"journal":{"name":"Naunyn-schmiedebergs Archives of Pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the benefits of astaxanthin as a functional food ingredient: Its effects on oxidative stress and reproductive outcomes in women with PCOS – A systematic review and single-arm meta-analysis of randomized clinical trials\",\"authors\":\"Victória Dogani Rodrigues, Beatriz Leme Boaro, Lívia Fornari Laurindo, Eduardo Federighi Baisi Chagas, Enzo Pereira de Lima, Lucas Fornari Laurindo, Sandra Maria Barbalho\",\"doi\":\"10.1007/s00210-024-03432-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Polycystic ovary syndrome (PCOS) is a prevalent gynecological-endocrinological disorder characterized by hyperandrogenism, menstrual irregularities, and metabolic disturbances. Recent research has highlighted the role of oxidative stress and chronic inflammation in exacerbating PCOS symptoms and impeding reproductive outcomes. Astaxanthin, a potent antioxidant found in marine organisms, has been suggested as a potential therapeutic intervention due to its ability to reduce oxidative stress and inflammation. This meta-analysis systematically reviews randomized controlled trials assessing the impact of astaxanthin supplementation on oxidative stress and reproductive outcomes in women with PCOS. Data from four trials were analyzed, focusing on markers of oxidative stress and reproductive health metrics. The meta-analysis utilized fixed and random-effects models to synthesize results, with heterogeneity assessed using Chi-square and I<sup>2</sup> statistics. The findings indicate that while astaxanthin significantly improves markers of total antioxidant capacity (TAC) in follicular fluid, it does not show a consistent effect on other oxidative stress biomarkers such as malondialdehyde (MDA), catalase (CAT), or superoxide dismutase (SOD). Reproductive outcomes, including oocyte quality and the number of high-quality embryos, showed moderate improvements, although effects on fertilization rates and pregnancy outcomes were insignificant. The analysis highlights variability in study designs and dosing, suggesting a need for further research with standardized protocols and larger sample sizes. Future studies should focus on determining optimal dosing, exploring mechanistic pathways, and investigating the combined effects of astaxanthin with other interventions. Longitudinal studies are needed to assess long-term benefits and safety, and personalized approaches could enhance treatment efficacy for individuals with PCOS.</p>\",\"PeriodicalId\":18862,\"journal\":{\"name\":\"Naunyn-schmiedebergs Archives of Pharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Naunyn-schmiedebergs Archives of Pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s00210-024-03432-w\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Naunyn-schmiedebergs Archives of Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00210-024-03432-w","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

多囊卵巢综合征(PCOS)是一种常见的妇科内分泌疾病,其特点是雄激素过多、月经不调和代谢紊乱。最近的研究强调了氧化应激和慢性炎症在加重多囊卵巢综合征症状和阻碍生殖结果方面的作用。虾青素是一种存在于海洋生物体中的强效抗氧化剂,由于其能够减少氧化应激和炎症,因此被认为是一种潜在的治疗干预措施。这项荟萃分析系统地回顾了随机对照试验,评估了补充虾青素对多囊卵巢综合症女性氧化应激和生殖结果的影响。分析了四项试验的数据,重点关注氧化应激指标和生殖健康指标。荟萃分析采用固定效应和随机效应模型来综合结果,并使用Chi-square和I2统计量评估异质性。研究结果表明,虽然虾青素能显著提高卵泡液中的总抗氧化能力(TAC)指标,但它对其他氧化应激生物标志物(如丙二醛(MDA)、过氧化氢酶(CAT)或超氧化物歧化酶(SOD))的影响并不一致。包括卵母细胞质量和优质胚胎数量在内的生殖结果有适度改善,但对受精率和妊娠结果的影响不显著。分析强调了研究设计和剂量方面的差异,表明有必要通过标准化方案和更大的样本量开展进一步研究。今后的研究应侧重于确定最佳剂量、探索机理途径,以及调查虾青素与其他干预措施的综合效果。需要进行纵向研究以评估长期益处和安全性,个性化方法可提高多囊卵巢综合症患者的治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Exploring the benefits of astaxanthin as a functional food ingredient: Its effects on oxidative stress and reproductive outcomes in women with PCOS – A systematic review and single-arm meta-analysis of randomized clinical trials

Exploring the benefits of astaxanthin as a functional food ingredient: Its effects on oxidative stress and reproductive outcomes in women with PCOS – A systematic review and single-arm meta-analysis of randomized clinical trials

Polycystic ovary syndrome (PCOS) is a prevalent gynecological-endocrinological disorder characterized by hyperandrogenism, menstrual irregularities, and metabolic disturbances. Recent research has highlighted the role of oxidative stress and chronic inflammation in exacerbating PCOS symptoms and impeding reproductive outcomes. Astaxanthin, a potent antioxidant found in marine organisms, has been suggested as a potential therapeutic intervention due to its ability to reduce oxidative stress and inflammation. This meta-analysis systematically reviews randomized controlled trials assessing the impact of astaxanthin supplementation on oxidative stress and reproductive outcomes in women with PCOS. Data from four trials were analyzed, focusing on markers of oxidative stress and reproductive health metrics. The meta-analysis utilized fixed and random-effects models to synthesize results, with heterogeneity assessed using Chi-square and I2 statistics. The findings indicate that while astaxanthin significantly improves markers of total antioxidant capacity (TAC) in follicular fluid, it does not show a consistent effect on other oxidative stress biomarkers such as malondialdehyde (MDA), catalase (CAT), or superoxide dismutase (SOD). Reproductive outcomes, including oocyte quality and the number of high-quality embryos, showed moderate improvements, although effects on fertilization rates and pregnancy outcomes were insignificant. The analysis highlights variability in study designs and dosing, suggesting a need for further research with standardized protocols and larger sample sizes. Future studies should focus on determining optimal dosing, exploring mechanistic pathways, and investigating the combined effects of astaxanthin with other interventions. Longitudinal studies are needed to assess long-term benefits and safety, and personalized approaches could enhance treatment efficacy for individuals with PCOS.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信