不同激素受体乳腺癌亚型中乳腺癌风险因素的因果效应：双样本孟德尔随机研究

medRxiv - Epidemiology Pub Date : 2024-09-03 DOI:10.1101/2024.09.02.24312928

Renée MG Verdiesen, Mehrnoosh Shokouhi, Stephen Burgess, Sander Canisius, Jenny Chang-Claude, Stig E Bojesen, Marjanka K Schmidt

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引用次数: 0

摘要

背景目前尚不清楚既定的乳腺癌风险因素是否对不同激素受体乳腺癌亚型产生类似的因果效应。我们估计并比较了身高、体重指数 (BMI)、2 型糖尿病、初潮年龄、绝经年龄、乳房密度、饮酒量、经常吸烟和体育锻炼在这些亚型中的因果关系估计值。

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Causal effects of breast cancer risk factors across hormone receptor breast cancer subtypes: A two-sample Mendelian randomization study

Background It is unclear if established breast cancer risk factors exert similar causal effects across hormone receptor breast cancer subtypes. We estimated and compared causal estimates of height, body mass index (BMI), type 2 diabetes, age at menarche, age at menopause, breast density, alcohol consumption, regular smoking, and physical activity across these subtypes.

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medRxiv - Epidemiology

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