密闭环境中的活性液-液相分离

Chen Lin, Robijn Bruinsma
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引用次数: 0

摘要

封闭环境中的活性液-液相分离(LLPS)被认为在细胞生物学中发挥着重要作用。最近的研究表明,当成核与生长的经典理论中包含微观层面的主动噪声时,只要液滴半径是唯一的集合坐标,就不会导致文本{微观}层面的详细平衡崩溃。在这里,我们提出了一个在约束环境中活动的LLPS的简单模型,将液滴在约束势中的位置作为第二个集体坐标,并利用波动-消散定理(Fluctuation-Dissipation Theorem)作为诊断方法,发现详细平衡在宏观水平上以一种不同寻常的方式被打破了。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Active Liquid-Liquid Phase-Separation in a Confining Environment
Active liquid-liquid phase separation (LLPS) in a confining environment is believed to play an important role in cell biology. Recently, it was shown that when active noise at the microscopic level is included in the classical theory of nucleation and growth then this does not cause the breakdown of detailed balance at the \textit{macroscopic} level provided that the droplet radius is the only collective coordinate. Here, we present a simple model for active LLPS in a confining environment, with the droplet location in a confining potential as a second collective coordinate, and find that detailed balance \textit{is} broken at the macroscopic level in an unusual fashion, using the Fluctuation-Dissipation Theorem as a diagnostic.
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