Chris Siu Yeung Chow, Sumedha Negi, Shaine Chenxin Bao, Chen Fang, James Edward Hudson, Woo Jun Shim, Yuanzhao Cao, Nathan Palpant
{"title":"以社区为导向、数据驱动的资源，用于改进人类多能干细胞心脏建模的方案设计","authors":"Chris Siu Yeung Chow, Sumedha Negi, Shaine Chenxin Bao, Chen Fang, James Edward Hudson, Woo Jun Shim, Yuanzhao Cao, Nathan Palpant","doi":"10.1101/2024.09.04.611313","DOIUrl":null,"url":null,"abstract":"Protocols for culturing cardiac cells derived from human-induced pluripotent stem cells (hiPSCs) are critical for studying mechanisms of development and disease. This study provides analysis of a community-oriented database to assess parameters used in published cardiac differentiation protocols, including a web-accessible portal for user-guided customisation of protocols. Validation studies support context-dependent roles for media composition in deriving functional maturation of hiPSC-derived cardiomyocytes.","PeriodicalId":501269,"journal":{"name":"bioRxiv - Developmental Biology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A community-oriented, data-driven resource to improve protocol design for cardiac modelling from human pluripotent stem cells\",\"authors\":\"Chris Siu Yeung Chow, Sumedha Negi, Shaine Chenxin Bao, Chen Fang, James Edward Hudson, Woo Jun Shim, Yuanzhao Cao, Nathan Palpant\",\"doi\":\"10.1101/2024.09.04.611313\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Protocols for culturing cardiac cells derived from human-induced pluripotent stem cells (hiPSCs) are critical for studying mechanisms of development and disease. This study provides analysis of a community-oriented database to assess parameters used in published cardiac differentiation protocols, including a web-accessible portal for user-guided customisation of protocols. Validation studies support context-dependent roles for media composition in deriving functional maturation of hiPSC-derived cardiomyocytes.\",\"PeriodicalId\":501269,\"journal\":{\"name\":\"bioRxiv - Developmental Biology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"bioRxiv - Developmental Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.09.04.611313\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"bioRxiv - Developmental Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.04.611313","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A community-oriented, data-driven resource to improve protocol design for cardiac modelling from human pluripotent stem cells
Protocols for culturing cardiac cells derived from human-induced pluripotent stem cells (hiPSCs) are critical for studying mechanisms of development and disease. This study provides analysis of a community-oriented database to assess parameters used in published cardiac differentiation protocols, including a web-accessible portal for user-guided customisation of protocols. Validation studies support context-dependent roles for media composition in deriving functional maturation of hiPSC-derived cardiomyocytes.
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