经典迷幻药的免疫调节作用:临床前研究的系统回顾。

Zhen Xuen Brandon Low,Wei Shen Ng,Eugene Sheng Yao Lim,Bey Hing Goh,Yatinesh Kumari
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引用次数: 0

摘要

新的证据表明,经典迷幻药具有免疫调节和抗炎特性;然而,这些作用尚未得到充分证实。本系统综述旨在及时、全面地概述经典迷幻药在临床前研究中的免疫调节作用。我们在六个数据库中进行了系统检索,包括 CINAHL、EMBASE、MEDLINE、PsychINFO、Scopus 和 Web of Science。针对经典迷幻药评估其对炎症指标和免疫调节作用的符合条件的研究已被纳入分析范围。从 2822 篇符合条件的文章中提取了 40 篇的数据,并使用实验动物实验系统综述中心(SYRCLE)工具和体外研究质量评估工具(QUIN)对其偏倚风险进行了评估。研究内容包括:2,5-二甲氧基-4-碘苯丙胺(DOI;n = 18);迷幻药(4-PO-DMT;n = 9);N,N-二甲基色胺(DMT;n = 8);麦角酰二乙胺(4-PO-DMT;n = 9);麦角酰二乙胺(LSD;n = 6);5-甲氧基-N,N-二甲基色胺(5-MeO-DMT;n = 3);迷幻药(4-HO-DMT;n = 3);以及麦司卡林(n = 2)。在服用迷幻药后测量炎症细胞因子水平的 36 项研究中,有 29 项研究观察到至少一种炎症细胞因子水平下降。有 10 项研究对免疫细胞的活性进行了评估,结果不一,有相同数量的研究(10 项中有 5 项)报告免疫细胞的活性增加或减少。研究发现,在正常生理条件下服用经典迷幻药可减轻原有炎症,但会促进炎症。预计这些信息将为未来的临床试验提供参考,探索经典迷幻药在各种病症中缓解炎症的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The immunomodulatory effects of classical psychedelics: A systematic review of preclinical studies.
Emerging evidence suggests that classical psychedelics possess immunomodulatory and anti-inflammatory properties; however, these effects are yet to be well-established. This systematic review aims to provide a timely and comprehensive overview of the immunomodulatory effects of classical psychedelics in preclinical studies. A systematic search was conducted on six databases, including CINAHL, EMBASE, MEDLINE, PsychINFO, Scopus, and Web of Science. Eligible studies targeting classical psychedelics for evaluation of their effects on inflammatory markers and immunomodulation have been included for analysis. Data was extracted from 40 out of 2822 eligible articles, and their risk of bias was assessed using the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) tool and Quality Assessment Tool for In Vitro Studies (QUIN). Studies examined 2,5-dimethoxy-4-iodoamphetamine (DOI; n = 18); psilocybin (4-PO-DMT; n = 9); N,N-dimethyltryptamine (DMT; n = 8); lysergic acid diethylamide (LSD; n = 6); 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT; n = 3); psilocin (4-HO-DMT; n = 3); and mescaline (n = 2). In 36 studies where inflammatory cytokine levels were measured following psychedelic administration, a decrease in at least one inflammatory cytokine was observed in 29 studies. Immune cell activity was assessed in 10 studies and findings were mixed, with an equal number of studies (n = 5 out of 10) reporting either an increase or decrease in immune cell activity. Classical psychedelics were found to alleviate pre-existing inflammation but promote inflammation when administered under normal physiological conditions. This information is anticipated to inform future clinical trials, exploring classical psychedelics' potential to alleviate inflammation in various pathologies.
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