IL-10单核苷酸多态性（rs1800871、rs1800872和rs1800896）与COVID-19严重程度的关系

IF 1.1 4区生物学 Q4 GENETICS & HEREDITY

Genetic testing and molecular biomarkers Pub Date : 2024-09-10 DOI:10.1089/gtmb.2024.0276

Hossein Azadinejad,Parisa Feizollahi,Alireza Rezaeimanesh,Farhad Salari,Ali Gorgin Karaji

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引用次数: 0

摘要

背景：白细胞介素-10（IL-10）是一种抗炎细胞因子：白细胞介素-10（IL-10）是一种抗炎细胞因子，在严重的 COVID-19 患者中其水平会升高。IL-10 多态性可能在增加 IL-10 水平和 COVID-19 严重程度中发挥作用。本研究旨在调查伊朗克尔曼沙阿省患者的 IL-10 单核苷酸多态性（SNPs）（rs1800896 [-1082 C < T]、rs1800871 [-819 A > G] 和 rs1800872 [-592 T > G]）与 COVID-19 严重程度之间的关系。研究方法共有 150 名轻度 COVID-19 患者（84 名男性和 66 名女性，年龄为 40.1 ± 12.44 岁）和 143 名重度 COVID-19 患者（76 名男性和 67 名女性，年龄为 61.04 ± 15.65 岁）参与了本研究。研究人员采集了患者的血样，提取了 DNA，并采用聚合酶链式反应-限制性片段长度多态性方法测定了各 SNPs 的基因型。结果显示研究结果显示，三个SNPs的基因型与COVID-19的严重程度无显著关系（P>0.05）。结论根据我们的研究结果，这些 SNP 与克尔曼沙阿患者的 COVID-19 严重程度无关。

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Relationship Between IL-10 Single Nucleotide Polymorphisms (rs1800871, rs1800872, and rs1800896) and the Severity of COVID-19.

Background: Interleukin-10 (IL-10) is an anti-inflammatory cytokine whose levels are elevated in patients with severe COVID-19. IL-10 polymorphisms may play a role in increasing IL-10 levels and the severity of COVID-19. This study aimed to investigate the relationship between IL-10 single nucleotide polymorphisms (SNPs) (rs1800896 [-1082 C < T], rs1800871 [-819 A > G], and rs1800872 [-592 T > G]) and the severity of COVID-19 in patients from Kermanshah Province, Iran. Methods: A total of 150 patients with mild COVID-19 (84 men and 66 women aged 40.1 ± 12.44 years) and 143 patients with severe COVID-19 (76 men and 67 women aged 61.04 ± 15.65 years) participated in this study. Blood samples were collected from the patients, DNA was extracted, and the genotype of each SNPs was determined using the polymerase chain reaction-restriction fragment length polymorphism method. Result: The results of this study did not show a significant relationship between the genotypes of the three studied SNPs and the severity of COVID-19 (p > 0.05). Conclusion: According to our findings, these SNPs were not associated with COVID-19 severity in patients in Kermanshah.

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来源期刊

Genetic testing and molecular biomarkers 生物-遗传学

CiteScore

2.50

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Genetic Testing and Molecular Biomarkers is the leading peer-reviewed journal covering all aspects of human genetic testing including molecular biomarkers. The Journal provides a forum for the development of new technology; the application of testing to decision making in an increasingly varied set of clinical situations; ethical, legal, social, and economic aspects of genetic testing; and issues concerning effective genetic counseling. This is the definitive resource for researchers, clinicians, and scientists who develop, perform, and interpret genetic tests and their results. Genetic Testing and Molecular Biomarkers coverage includes: -Diagnosis across the life span- Risk assessment- Carrier detection in individuals, couples, and populations- Novel methods and new instrumentation for genetic testing- Results of molecular, biochemical, and cytogenetic testing- Genetic counseling