N-Heterocyclic Carbene (NHC) 催化的丙烯酰胺尾对尾二聚化反应

Synthesis Pub Date : 2024-08-14 DOI:10.1055/s-0043-1775037
Chensheng Zhao, Bingwei Zhou
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引用次数: 0

摘要

丙烯酰胺的尾对尾二聚化可以形成二酰胺。然而,文献中只有一个 N,N-二甲基丙烯酰胺的实例。本文介绍了一种 NHC 催化的丙烯酰胺尾对尾二聚反应,收率中等至极佳。在这种情况下,N-芳基丙烯酰胺容易发生二聚反应,该反应具有反应效率高、E-选择性好和操作简便等特点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

N-Heterocyclic Carbene (NHC)-Catalyzed Tail-to-Tail Dimerization of Acrylamides

N-Heterocyclic Carbene (NHC)-Catalyzed Tail-to-Tail Dimerization of Acrylamides

The tail-to-tail dimerization of acrylamides enables the formation of diamides. However, only one example of N,N-dimethylacrylamide has been described in the literature. Herein, an NHC-catalyzed tail-to-tail dimerization of acrylamides in moderate to excellent yields is presented. In this context, N-arylacrylamides are susceptible to the dimerization reaction, which features high reaction efficiency, good E-selectivity, and easy operation.

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