{"title":"N-Heterocyclic Carbene (NHC) 催化的丙烯酰胺尾对尾二聚化反应","authors":"Chensheng Zhao, Bingwei Zhou","doi":"10.1055/s-0043-1775037","DOIUrl":null,"url":null,"abstract":"<p>The tail-to-tail dimerization of acrylamides enables the formation of diamides. However, only one example of <i>N</i>,<i>N</i>-dimethylacrylamide has been described in the literature. Herein, an NHC-catalyzed tail-to-tail dimerization of acrylamides in moderate to excellent yields is presented. In this context, <i>N</i>-arylacrylamides are susceptible to the dimerization reaction, which features high reaction efficiency, good <i>E</i>-selectivity, and easy operation.</p> ","PeriodicalId":501298,"journal":{"name":"Synthesis","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"N-Heterocyclic Carbene (NHC)-Catalyzed Tail-to-Tail Dimerization of Acrylamides\",\"authors\":\"Chensheng Zhao, Bingwei Zhou\",\"doi\":\"10.1055/s-0043-1775037\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The tail-to-tail dimerization of acrylamides enables the formation of diamides. However, only one example of <i>N</i>,<i>N</i>-dimethylacrylamide has been described in the literature. Herein, an NHC-catalyzed tail-to-tail dimerization of acrylamides in moderate to excellent yields is presented. In this context, <i>N</i>-arylacrylamides are susceptible to the dimerization reaction, which features high reaction efficiency, good <i>E</i>-selectivity, and easy operation.</p> \",\"PeriodicalId\":501298,\"journal\":{\"name\":\"Synthesis\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Synthesis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1055/s-0043-1775037\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synthesis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/s-0043-1775037","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
N-Heterocyclic Carbene (NHC)-Catalyzed Tail-to-Tail Dimerization of Acrylamides
The tail-to-tail dimerization of acrylamides enables the formation of diamides. However, only one example of N,N-dimethylacrylamide has been described in the literature. Herein, an NHC-catalyzed tail-to-tail dimerization of acrylamides in moderate to excellent yields is presented. In this context, N-arylacrylamides are susceptible to the dimerization reaction, which features high reaction efficiency, good E-selectivity, and easy operation.