发现过程化学:学术界、制药业和合同研究组织之间的创新枢纽

Synthesis Pub Date : 2024-09-11 DOI:10.1055/a-2380-6425
Matthew A. Horwitz
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引用次数: 0

摘要

发现过程化学(DPC)是一个新兴的跨部门领域,其特点是开发新的化学反应或合成方法,从而高效地阐明结构-活性关系(SAR)和结构-性质关系(SPR),并快速过渡到过程开发。这些努力加速了药物的发现和开发,因此学术界和工业界的化学家都越来越重视这些目标。在本短评中,我们将探讨 DPC 的最新进展及其对 SAR/SPR 研究和下游药物开发工作的影响。1 引言 2 利用生物异构体进行 SAR/SPR 探究 3 可多元化反应伙伴的偶联物 4 后期官能化 5 结论与展望
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Discovery Process Chemistry: An Innovation Hub at the Interface of Academia, the Pharmaceutical Industry, and Contract Research Organization

Discovery Process Chemistry: An Innovation Hub at the Interface of Academia, the Pharmaceutical Industry, and Contract Research Organization

Discovery Process Chemistry (DPC) is an emerging intersectoral space that is characterized by the development of new chemical reactions or syntheses that enable the efficient elucidation of structure-activity relationships (SARs) and structure-property relationships (SPRs) as well as a rapid transition to process development. Drug discovery and development are accelerated by such efforts and this has led chemists in academia and industry alike to place an increasing importance on these aims. In this Short Review, we explore recent advances in DPC and the impact that it can have on SAR/SPR interrogation and downstream drug development efforts.

1 Introduction

2 Enabling SAR/SPR Interrogation with Bioisosteres

3 Couplings of Diversifiable Reaction Partners

4 Late-Stage Functionalization

5 Conclusion and Outlook

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