重氮膦酸盐化学的最新进展:反应与转化

Synthesis Pub Date : 2024-09-05 DOI:10.1055/s-0040-1720129
Saif Ullah, Zulfiqar Hussain, Yungui Peng
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引用次数: 0

摘要

重氮膦酸盐是有机化学领域中不可或缺的合成中间体,可作为多种分子的前体,并具有作为生物活性化合物的潜在应用价值。α-重氮甲基膦酸盐在不对称转化过程中,尤其是与合适的催化剂体系结合使用时,表现出广阔的反应活性和较高的对映选择性。本综述汇编了 2016 年至 2024 年重氮膦酸盐化学领域的最新进展,重点介绍了它们在有机合成中的反应活性和转化潜力。重氮膦酸盐被视为革命性化合物,作为碳烯前体表现出独特的属性,可推动多种化学反应,如[3+2]环加成反应、不对称[3+2]环加成反应、不对称[3+3]环加成反应和不对称取代反应。它们在官能团转换中的适应性突出了它们在各种合成方法中的关键作用。这篇综述强调了合成化学家对重氮膦酸盐反应日益增长的兴趣,促进了新型合成策略的发展并扩大了它们的应用范围。重氮膦酸盐作为试剂、合成中间体、前体和催化剂的多方面用途凸显了它们在现代有机化学和医药应用中的重要意义,促使人们进一步探索这一充满活力的领域。1 引言 2 [3+2] 环化反应 3 不对称 [3+2] 环化反应 4 不对称 [3+3] 环化反应 5 不对称取代反应 6 作为羰基前体的重氮膦酸盐 7 重氮膦酸盐在含氟化合物化学中的应用 8 其他反应 9 未来发展方向 10 结论
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Recent Advances in Diazophosphonate Chemistry: Reactions and Transformations

Recent Advances in Diazophosphonate Chemistry: Reactions and Transformations

Diazophosphonates function as indispensable synthetic intermediates within the domain of organic chemistry, serving as precursors for a diverse range of molecules, with potential applications as bioactive compounds. α-Diazomethylphosphonates showcase expansive reactivity and elevated levels of enantioselectivity in asymmetric transformations, especially in conjunction with suitable catalyst systems. This review compiles the latest advancements in diazophosphonate chemistry from 2016 to 2024, highlighting their reactivity and transformative potential in organic synthesis. Diazophosphonates, regarded as revolutionary compounds, exhibit unique attributes as carbene precursors, driving diverse chemical reactions such as [3+2] cycloaddition, asymmetric [3+2] cycloaddition, asymmetric [3+3] cycloaddition, and asymmetric substitution reactions. Their adaptability in functional group conversions underscores their pivotal role in various synthetic methodologies. The review highlights the growing interest in diazophosphonate reactions among synthetic chemists, fostering novel synthetic strategies and expanding their application horizons. The multifaceted utility of diazophosphonates as reagents, synthetic intermediates, precursors, and catalysts underscores their significance in modern organic chemistry and pharmaceutical applications, prompting further exploration into this dynamic field.

1 Introduction

2 [3+2] Cycloaddition Reactions

3 Asymmetric [3+2] Cycloaddition Reactions

4 Asymmetric [3+3] Cycloaddition Reactions

5 Asymmetric Substitution Reactions

6 Diazophosphonates as Carbene Precursors

7 Diazophosphonates in the Chemistry of Fluorinated Compounds

8 Other Reactions

9 Future Directions

10 Conclusion

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