综合重配分析揭示 H5N8 甲型流感病毒的复杂进化动态

Viruses Pub Date : 2024-09-03 DOI:10.3390/v16091405

Egor Degtyarev, Sofia Feoktistova, Pavel Volchkov, Andrey Deviatkin

{"title":"综合重配分析揭示 H5N8 甲型流感病毒的复杂进化动态","authors":"Egor Degtyarev, Sofia Feoktistova, Pavel Volchkov, Andrey Deviatkin","doi":"10.3390/v16091405","DOIUrl":null,"url":null,"abstract":"Influenza A viruses (IAVs) circulate among different species and have the potential to cause significant pandemics in humans. This study focuses on reassortment events in the H5N8 subtype of IAV, which poses a serious threat to public health due to its high pathogenicity in birds and potential for cross-species transmission. We retrieved 2359 H5N8 IAV sequences from GISAID, and filtered and analyzed 442 complete genomic sequences for reassortment events using pairwise distance deviation matrices (PDDMs) and pairwise distance correspondence plots (PDCPs). This detailed case study of specific H5N8 viruses revealed previously undescribed reassortment events, highlighting the complex evolutionary history and potential pandemic threat of H5N8 IAVs.","PeriodicalId":501326,"journal":{"name":"Viruses","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Complex Evolutionary Dynamics of H5N8 Influenza A Viruses Revealed by Comprehensive Reassortment Analysis\",\"authors\":\"Egor Degtyarev, Sofia Feoktistova, Pavel Volchkov, Andrey Deviatkin\",\"doi\":\"10.3390/v16091405\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Influenza A viruses (IAVs) circulate among different species and have the potential to cause significant pandemics in humans. This study focuses on reassortment events in the H5N8 subtype of IAV, which poses a serious threat to public health due to its high pathogenicity in birds and potential for cross-species transmission. We retrieved 2359 H5N8 IAV sequences from GISAID, and filtered and analyzed 442 complete genomic sequences for reassortment events using pairwise distance deviation matrices (PDDMs) and pairwise distance correspondence plots (PDCPs). This detailed case study of specific H5N8 viruses revealed previously undescribed reassortment events, highlighting the complex evolutionary history and potential pandemic threat of H5N8 IAVs.\",\"PeriodicalId\":501326,\"journal\":{\"name\":\"Viruses\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Viruses\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/v16091405\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Viruses","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/v16091405","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

甲型流感病毒（IAV）在不同物种间流行，并有可能在人类中引起重大流行。本研究的重点是 H5N8 亚型 IAV 的重配事件，该亚型 IAV 在鸟类中具有高致病性和跨物种传播的潜力，对公共卫生构成严重威胁。我们从 GISAID 中检索到 2359 条 H5N8 IAV 序列，并使用成对距离偏差矩阵（PDDM）和成对距离对应图（PDCP）过滤和分析了 442 条完整的基因组序列，以寻找重配事件。这项针对特定 H5N8 病毒的详细案例研究揭示了以前未曾描述过的重配事件，凸显了 H5N8 IAV 复杂的进化历史和潜在的大流行威胁。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Complex Evolutionary Dynamics of H5N8 Influenza A Viruses Revealed by Comprehensive Reassortment Analysis

Influenza A viruses (IAVs) circulate among different species and have the potential to cause significant pandemics in humans. This study focuses on reassortment events in the H5N8 subtype of IAV, which poses a serious threat to public health due to its high pathogenicity in birds and potential for cross-species transmission. We retrieved 2359 H5N8 IAV sequences from GISAID, and filtered and analyzed 442 complete genomic sequences for reassortment events using pairwise distance deviation matrices (PDDMs) and pairwise distance correspondence plots (PDCPs). This detailed case study of specific H5N8 viruses revealed previously undescribed reassortment events, highlighting the complex evolutionary history and potential pandemic threat of H5N8 IAVs.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Viruses

自引率

0.00%

发文量