{"title":"铱催化转移加氢法高效还原胺化 5-羟甲基糠醛","authors":"","doi":"10.1039/d4cy00812j","DOIUrl":null,"url":null,"abstract":"<div><div>Transfer hydrogenative reductive amination of 5-(hydroxymethy)furfural (HMF) has been accomplished, catalysed by a cyclometalated iridium catalyst with formic acid as a hydrogen source. The catalytic system afforded a TON of 9600 and TOF of 14 400 h<sup>−1</sup>, and the reaction can be successfully scaled up to a 10 gram scale at a substrate-to-catalyst ratio of 10 000. A wide range of amines could be coupled with HMF to afford furan derived products, including modified drug molecules, key intermediates for drug synthesis and potential monomers for polymer synthesis.</div></div>","PeriodicalId":66,"journal":{"name":"Catalysis Science & Technology","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficient reductive amination of 5-hydroxymethylfurfural by iridium-catalysed transfer hydrogenation†\",\"authors\":\"\",\"doi\":\"10.1039/d4cy00812j\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Transfer hydrogenative reductive amination of 5-(hydroxymethy)furfural (HMF) has been accomplished, catalysed by a cyclometalated iridium catalyst with formic acid as a hydrogen source. The catalytic system afforded a TON of 9600 and TOF of 14 400 h<sup>−1</sup>, and the reaction can be successfully scaled up to a 10 gram scale at a substrate-to-catalyst ratio of 10 000. A wide range of amines could be coupled with HMF to afford furan derived products, including modified drug molecules, key intermediates for drug synthesis and potential monomers for polymer synthesis.</div></div>\",\"PeriodicalId\":66,\"journal\":{\"name\":\"Catalysis Science & Technology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2024-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Catalysis Science & Technology\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S2044475324004659\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Catalysis Science & Technology","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S2044475324004659","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Efficient reductive amination of 5-hydroxymethylfurfural by iridium-catalysed transfer hydrogenation†
Transfer hydrogenative reductive amination of 5-(hydroxymethy)furfural (HMF) has been accomplished, catalysed by a cyclometalated iridium catalyst with formic acid as a hydrogen source. The catalytic system afforded a TON of 9600 and TOF of 14 400 h−1, and the reaction can be successfully scaled up to a 10 gram scale at a substrate-to-catalyst ratio of 10 000. A wide range of amines could be coupled with HMF to afford furan derived products, including modified drug molecules, key intermediates for drug synthesis and potential monomers for polymer synthesis.
期刊介绍:
A multidisciplinary journal focusing on cutting edge research across all fundamental science and technological aspects of catalysis.
Editor-in-chief: Bert Weckhuysen
Impact factor: 5.0
Time to first decision (peer reviewed only): 31 days