对 MINERVA 进行 FAIR 评估,以此为契机促进系统生物医学领域的开放科学和科学众包

Irina Balaur, Danielle Welter, Adrien Rougny, Esther Thea Inau, Alexander Mazein, Soumyabrata Ghosh, Reinhard Schneider, Dagmar Waltemath, Marek Ostaszewski, Venkata Satagopam
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引用次数: 0

摘要

疾病地图项目(https://disease-maps.org)致力于开发支持转化医学研究的特定疾病综合结构化知识库。这些疾病地图需要持续的跨学科合作,而且应该是可重复使用和可互操作的。遵循可查找、可访问、可互操作和可重用(FAIR)原则可提高此类数字资产的效用。我们使用 RDA FAIR 数据成熟度模型评估了分子交互近红外可视化(MINERVA)平台的 FAIR 性。MINERVA 是一个独立的网络服务器,允许用户手动或编程管理、探索和分析疾病图谱及其相关数据。我们在帕金森病地图(PD 地图)和 COVID-19 疾病地图上演示了 FAIR 评估,这两个地图是疾病地图项目下的大型项目,分别旨在研究帕金森病和 SARS-CoV-2 感染的分子机制。我们讨论了MINERVA平台支持的FAIR功能,并概述了进一步提高MINERVA的FAIR性以及更好地将这一资源与其他正在进行的支持计算系统生物医学FAIR的科学计划联系起来的步骤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
FAIR assessment of MINERVA as an opportunity to foster open science and scientific crowdsourcing in systems biomedicine
The Disease Maps Project (https://disease-maps.org) focuses on the development of disease-specific comprehensive structured knowledge repositories supporting translational medicine research. These disease maps require continuous interdisciplinary collaboration, and they should be reusable and interoperable. Adhering to the Findable, Accessible, Interoperable and Reusable (FAIR) principles enhances the utility of such digital assets. We used the RDA FAIR Data Maturity Model and assessed the FAIRness of the Molecular Interaction NEtwoRk VisuAlization (MINERVA) Platform. MINERVA is a standalone webserver that allows users to manage, explore and analyze disease maps and their related data manually or programmatically. We exemplify the FAIR assessment on the Parkinson's Disease Map (PD map) and the COVID-19 Disease Map, which are large-scale projects under the umbrella of the Disease Maps Project, aiming to investigate molecular mechanisms of the Parkinson's disease and SARS-CoV-2 infection, respectively. We discuss the FAIR features supported by the MINERVA Platform and we outline steps to further improve the MINERVA FAIRness and to better connect this resource to other ongoing scientific initiatives supporting FAIR in computational systems biomedicine.
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