中性粒细胞胞外捕获器在炎症性风湿病中的作用。

IF 5.2 2区医学 Q1 RHEUMATOLOGY

Current opinion in rheumatology Pub Date : 2024-09-12 DOI:10.1097/bor.0000000000001054

Norio Hanata,Mariana J Kaplan

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引用次数: 0

摘要

综述目的据报道，在几种炎症性风湿病中，中性粒细胞胞外捕获物（NET）的形成和降解发生了失调。本综述总结了最近在了解中性粒细胞胞外捕获物在炎症性风湿病中的作用方面取得的进展。最新发现大血管炎和多发性风湿性关节炎患者的外周血中中性粒细胞胞外捕获物的形成增强。在自身免疫性疾病的受影响器官中检测到 NET，它们可能在组织中发挥病理作用。一些未被充分研究的药物和补充剂可抑制 NET 的形成，并改善炎症性风湿病的动物模型。越来越多的证据表明，NET失调是多种炎症性风湿病发病机制的重要因素。关于调节炎症性风湿病中异常 NET 的形成和清除对临床的影响，还需要进一步研究。

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The role of neutrophil extracellular traps in inflammatory rheumatic diseases.

PURPOSE OF REVIEW Dysregulation in neutrophil extracellular trap (NET) formation and degradation has been reported in several inflammatory rheumatic diseases. This review summarizes the recent advances in the understanding the role of NETs in the context of inflammatory rheumatic diseases. RECENT FINDINGS NET formation is enhanced in peripheral blood of patients with large vessel vasculitis and polymyalgia rheumatica. NETs are detected in affected organs in autoimmune conditions, and they might play pathological roles in tissues. Several understudied medications and supplements suppress NET formation and ameliorate animal models of inflammatory rheumatic diseases. NETs and anti-NET antibodies have potential utility as disease biomarkers. SUMMARY Growing evidence has suggested the contribution of NET dysregulation to the pathogenesis of several inflammatory rheumatic diseases. Further research is warranted in regard to clinical impact of modulating aberrant NET formation and clearance in inflammatory rheumatic diseases.

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来源期刊

Current opinion in rheumatology 医学-风湿病学

CiteScore

9.70

自引率

2.00%

发文量

审稿时长

6-12 weeks

期刊介绍： A high impact review journal which boasts an international readership, Current Opinion in Rheumatology offers a broad-based perspective on the most recent and exciting developments within the field of rheumatology. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include vasculitis syndromes, medical physiology and rheumatic diseases, crystal deposition diseases and rheumatoid arthritis. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.